This study examined rare fungal infections in 30 critically ill adult patients over 18 years, finding that infections caused by uncommon yeasts like Trichosporon and Rhodotorula affected mainly long-term ICU patients with central lines. Despite treatment with antifungal medications, about 37% of patients died, highlighting the serious nature of these infections. The research emphasizes the importance of quickly identifying the specific fungus causing infection and using appropriate medications, along with removing infected catheters, to improve patient survival.