Research Keyword: randomized controlled trial

Efficacy of Topical Antifungal Nail Solution Versus Topical Placebo Solution for the Treatment of Pedal Onychomycosis: A Randomized Controlled Trial

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This study tested whether a new antifungal solution called Tolcylen® could effectively treat toenail fungus compared to a placebo. Over 9 months, participants using the active treatment showed dramatic improvements, with over half achieving complete fungal elimination and 70% showing significant nail healing. Beyond just getting rid of the fungus, patients reported much better quality of life with less discomfort and improved appearance as early as 3 months into treatment.

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Randomized control trial to study the effectiveness of tablet Fluconazole, capsule Itraconazole and tablet Terbinafine in superficial dermatophytosis

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This study tested three common antifungal medications used to treat fungal skin infections like ringworm. The research involved 180 patients who were randomly given one of three drugs and then checked at 4 and 8 weeks to see if the infection was gone. Itraconazole worked best, clearing infections in about 87% of patients, followed by Fluconazole at 73%, and Terbinafine at 63%.

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The effect of chitosan supplementation on liver function, hepatic steatosis predictors, and metabolic indicators in adults with non-alcoholic fatty liver disease: a randomized, double-blinded, placebo-controlled, clinical trial

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This study tested whether taking chitosan supplements (a type of dietary fiber) helps people with fatty liver disease. Over 8 weeks, participants taking chitosan along with a calorie-reduced diet lost more weight, reduced their waist size, and showed improvement in liver enzyme levels compared to those taking placebo. However, the supplement did not significantly improve cholesterol, blood sugar, or other metabolic markers at the dose tested.

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