Research Keyword: random forest classification

Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome

This study examined fungi in the gut of people with fatty liver disease and found that certain fungal species are more common in diseased patients. By analyzing both gut fungi and blood chemicals, researchers discovered that fungi significantly influence metabolic substances related to liver health. A computer model combining information about gut fungi and bacteria could identify fatty liver disease with reasonable accuracy, suggesting that fungi could be useful for disease diagnosis and potential treatment.

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Cross-cohort microbiome-wide study reveals consistent alterations in the gut bacteriome, but not the gut mycobiome, in patients with hypertension

Researchers analyzed gut bacteria and fungi in hypertensive patients compared to healthy people across two regions in China. They found that hypertensive patients have significant changes in their gut bacteria, particularly an overgrowth of harmful species like Clostridium and a decrease in beneficial bacteria. Interestingly, fungi in the gut showed minimal differences. These bacterial changes could potentially be used as early warning signs for hypertension and might become targets for new treatments.

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Characterization of the gut mycobiome in patients with non-alcoholic fatty liver disease and correlations with serum metabolome

This research reveals that the types of fungi living in our gut are linked to fatty liver disease in ways we didn’t fully understand before. While researchers have long studied bacteria in our gut, they largely ignored fungi, which turns out to play an important role too. The study found that certain fungal species are more common in people with fatty liver disease, and these fungi influence the metabolites (chemical compounds) in the blood that affect liver health. By combining information about fungi, bacteria, and blood chemistry, scientists developed a test that could identify fatty liver disease with 77% accuracy, suggesting that looking at gut fungi could help doctors diagnose and treat this common liver condition.

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