Research Keyword: pyrimidine biosynthesis

Case Commentary: Successful use of olorofim for the treatment of multi-drug-resistant Lomentospora prolificans infection in a child

A young girl contracted a dangerous drug-resistant fungal infection in her knee after an injury, which failed to respond to standard antifungal treatments. Doctors obtained special access to an experimental antifungal drug called olorofim through a compassionate use program. The child showed improvement within two weeks and was completely cured after six months of treatment with no signs of the infection returning two years later, making this the first successful case of this new drug being used in a child.

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Olorofim activity against multidrug-resistant Fusarium unveils intra-species and inter-species variability

Researchers tested a new antifungal drug called olorofim against 253 different Fusarium fungi that infect humans. Fusarium is particularly dangerous for people with weakened immune systems and resists most common antifungals. The study found that olorofim works, but its effectiveness varies significantly depending on which type of Fusarium is present. While these lab results are promising, additional testing in animal models is needed before it can be used clinically.

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