Research Keyword: publication bias

Effects of classical psychedelics on implicit and explicit emotional empathy and cognitive empathy: a meta-analysis of MET task

This study compiled data from multiple research studies to understand how classical psychedelics like LSD, psilocybin, and ayahuasca affect empathy—the ability to understand and share others’ feelings. The findings show these substances significantly increase emotional empathy, helping people feel more connected to others’ emotions. However, they don’t appear to affect cognitive empathy, which is the mental ability to understand what others are thinking. These results suggest psychedelics may have therapeutic potential for improving social connection and emotional understanding.

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Selective outcome reporting and non-reporting in trials of psychedelic drugs for mental disorders

Researchers examined whether studies of three promising psychedelic drugs (esketamine, psilocybin, and MDMA) for treating mental health conditions were reporting their results fairly and completely. They found that nearly 29% of completed trials had no published results, and some studies changed which outcomes they reported on between registration and publication. This selective reporting could make these drugs appear more effective than they actually are.

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Acute effects of psilocybin on attention and executive functioning in healthy volunteers: a systematic review and multilevel meta-analysis

This comprehensive review examined how psilocybin affects thinking and attention. Researchers analyzed 13 studies and found that psilocybin slows down reaction times during tasks requiring focus and decision-making, though accuracy remains relatively stable. The effects increase with higher doses. Understanding these cognitive changes is important for both therapeutic applications and ensuring safe use of psilocybin in research and clinical settings.

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