proteomics – Page 3

Identification of Challenging Dermatophyte Species Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

mycolabadmin

This study shows that a specialized technique called MALDI-TOF mass spectrometry can quickly and accurately identify skin fungal infections caused by dermatophytes. By creating a library of local fungal strains from Taiwan and combining it with commercial databases, researchers achieved over 90% accuracy in identifying different dermatophyte species. This practical method could help doctors diagnose fungal infections faster and choose better treatments.

Dynamic proteomic changes and ultrastructural insights into Pochonia chlamydosporia’s parasitism of Parascaris equorum eggs

mycolabadmin

Researchers studied how a parasitic fungus called Pochonia chlamydosporia infects and destroys the eggs of harmful parasitic worms found in horses. Using advanced imaging and protein analysis, they discovered that the fungus uses different strategies at different stages of infection: first it attaches and creates damage, then it breaks down the egg shell, and finally it consumes the contents. This fungus could be used as a natural, eco-friendly solution to control parasitic worm infections in animals.

Optimized protein extraction protocol from human skin samples

mycolabadmin

Researchers developed an improved method for extracting and analyzing proteins from human skin samples. Using specialized equipment and chemical treatments, they were able to identify about 6,000 different proteins in skin tissue, which is significantly more than previous methods could detect. This new protocol is particularly useful for studying skin diseases like fungal infections and could help identify new treatments by revealing how proteins change in diseased skin.

Identification of Challenging Dermatophyte Species Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

mycolabadmin

This study shows how MALDI-TOF mass spectrometry, a rapid laboratory technique, can accurately identify different types of dermatophyte fungi that cause ringworm and other skin infections. By creating a customized reference library combining commercial and locally-collected fungal samples, researchers improved identification accuracy from 16% to 91%. This advancement helps doctors identify the specific fungus causing a skin infection more quickly and accurately, enabling better treatment decisions.

Dynamic proteomic changes and ultrastructural insights into Pochonia chlamydosporia’s parasitism of Parascaris equorum eggs

mycolabadmin

Scientists studied how a special fungus called Pochonia chlamydosporia attacks and destroys parasitic worm eggs. Using advanced microscopy and protein analysis, they tracked the fungus through three stages of infection and identified the specific proteins and processes it uses to break down the worm eggs. This research helps us understand how this fungus works so it can be better used as a natural pest control method to protect animals from harmful parasites.

Aspergillus fumigatus dsRNA virus promotes fungal fitness and pathogenicity in the mammalian host

mycolabadmin

A virus that infects the fungus Aspergillus fumigatus makes the fungus more dangerous by helping it survive stress and resist immune cell attack. When researchers removed the virus from the fungus, it became weaker and less harmful to infected mice. Treating infected mice with an antiviral drug called ribavirin reduced the virus, lowering fungal burden and improving survival, suggesting that targeting fungal viruses could be a new way to treat serious fungal infections.

Prevalence of Candida and Other Yeasts in Vulvovaginal Infections during Pregnancy: A 10-Year Serbian Survey

mycolabadmin

This study examined yeast infections in pregnant Serbian women over 10 years, finding that nearly half had positive tests. While Candida albicans was most common, many other yeast species were also identified, some of which are resistant to common antifungal medications. Using advanced laboratory techniques (MALDI-TOF MS), researchers found more accurate identification was possible, which is important since different yeasts require different treatments, especially during pregnancy when some medications can harm the baby.

Emerging Allergens: How Proallergenic Activity Disrupts Epithelial Barriers [Response to Letter]

mycolabadmin

Many people with allergies or asthma don’t know what’s causing their symptoms. Researchers are investigating whether fungi that grow on plants might be responsible for some of these unknown allergies. They found that certain plant fungi can trigger allergic and inflammatory responses in animal models, suggesting they could be allergens in humans. The team plans to identify the specific fungal proteins causing these reactions to develop better allergy diagnostic tests.

Integrated Transcriptomics–Proteomics Analysis Reveals the Response Mechanism of Morchella sextelata to Pseudodiploöspora longispora Infection

mycolabadmin

White mold disease is a major problem for morel mushroom farmers in China. Researchers identified the fungus causing this disease and studied how morel cells defend themselves. Using advanced molecular techniques, they found that morel cells respond to infection by changing their cell membranes and walls, and by activating protective proteins that fight oxidative stress. This research helps explain how the disease damages morels and could lead to developing stronger, disease-resistant mushroom varieties.

Exposure to Tebuconazole Drives Cross-Resistance to Clinical Triazoles in Aspergillus fumigatus

mycolabadmin

When farmers use antifungal pesticides called triazoles to protect crops, the fungi can develop resistance to these chemicals. This study found that when the fungus Aspergillus fumigatus is exposed to the agricultural triazole tebuconazole, it can become resistant not only to that pesticide but also to clinical triazole drugs used to treat human fungal infections. The resistant fungi maintain this resistance even when the pesticide is removed, suggesting that environmental pesticide use may threaten the effectiveness of medical antifungal treatments.

Research Keyword: proteomics