Research Keyword: proteomic analysis

Genetic Ablation of the Conidiogenesis Regulator Enhances Mycoprotein Production

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Researchers created genetically modified versions of a fungus (Fusarium venenatum) used to make mycoprotein, a meat alternative. By removing a gene controlling spore formation, they increased fungal growth by 22%, which could significantly reduce production costs. The modified fungus also contained more amino acids and showed no safety concerns in lab tests, making it a promising advancement for sustainable food production.

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Prevalence of Candida and Other Yeasts in Vulvovaginal Infections during Pregnancy: A 10-Year Serbian Survey

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This study examined yeast infections in pregnant Serbian women over 10 years, finding that nearly half had vulvovaginal yeast infections. While Candida albicans remained the most common cause, other yeast species are increasingly found and can be harder to treat. The research emphasizes the importance of accurate laboratory identification of yeast species to guide proper antifungal treatment and prevent serious complications for both mother and newborn.

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Biochemical characteristics of extracts from proallergenic microfungi Erysiphe palczewskii and Erysiphe convolvuli

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Researchers studied two types of fungi that cause powdery mildew on plants and can trigger allergies in people who breathe in their spores. They discovered that these fungi contain proteins that act as allergens, including special proteins that help fungi survive stress. The fungi also contain high levels of linoleic acid, a fatty acid that can increase inflammation in the body. This research helps scientists understand why these fungi can cause allergic reactions and could help develop better diagnostic tools for fungal allergies.

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PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

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This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous yeast infections caused by Candida albicans. When this protein is missing from immune cells, mice become much more susceptible to severe fungal infections. The study found that PTP1B helps immune cells called macrophages and neutrophils kill fungi effectively, and when it’s absent, these immune cells work poorly. This discovery suggests that targeting PTP1B could be a new way to help patients fight off serious fungal infections.

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Phospholipase PlcH is involved in the secretion of cell wall glycoproteins and contributes to the host immune response of Aspergillus fumigatus

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Researchers discovered that an enzyme called PlcH helps a dangerous mold called Aspergillus fumigatus release protective proteins into its cell wall. These proteins help the fungus survive and evade the immune system. When scientists removed the gene for PlcH, the fungus became weaker and more vulnerable to both antifungal drugs and immune cells, suggesting PlcH could be a target for new antifungal treatments.

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Genetic Ablation of the Conidiogenesis Regulator Enhances Mycoprotein Production

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Scientists created a genetically modified version of the Quorn fungus (Fusarium venenatum) by removing a gene that controls spore production. This modification caused the fungus to grow faster and produce more biomass while also containing higher levels of amino acids. When combined with another genetic modification, the fungus produced 22% more biomass than normal, which could significantly reduce costs for mycoprotein production used in meat alternative products.

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