Research Keyword: protein stability

Time- and temperature-dependent Pentraxin 3 stability in serum and bronchoalveolar lavage fluid samples

mycolabadmin

Researchers tested how stable Pentraxin 3, a protein marker for fungal infections, remains when stored under different conditions. They found that samples stored in freezers at −20°C or −80°C kept stable for months, making Pentraxin 3 a reliable marker for diagnosing serious fungal infections. However, samples stored at warm temperatures degraded quickly, so proper cold storage is essential for accurate test results.

Read More »

The VelB IDD promotes selective heterodimer formation of velvet proteins for fungal development

mycolabadmin

Fungi use special proteins called velvet factors to decide whether to make spores, form protective structures, or produce toxins. This research discovered that one velvet protein called VelB has a special flexible region that helps it choose the right partner protein to team up with. This teamwork determines what developmental path the fungus takes and what chemicals it produces, revealing a clever biological control system.

Read More »

Computational analysis of missense mutations in squalene epoxidase associated with terbinafine resistance in clinically reported dermatophytes

mycolabadmin

Certain fungal skin infections are becoming resistant to terbinafine, a common antifungal medication, due to genetic mutations in an enzyme called squalene epoxidase. Using computer models and analysis tools, researchers identified which mutations most strongly reduce the drug’s effectiveness and where the protein changes occur. Four specific mutations were found to prevent terbinafine from binding to its target, offering insights that could help develop better antifungal treatments.

Read More »
Scroll to Top