Research Keyword: protein-protein interactions

A mycovirus enhances fitness of an insect pathogenic fungus and potentially modulates virulence through interactions between viral and host proteins

mycolabadmin

Scientists discovered a virus that infects a beneficial fungus used to control insect pests. Instead of harming the fungus, this virus makes it much better at its job by doubling spore production, helping it survive harsh conditions like UV radiation and heat, and making it more deadly to target insects. The improvement comes from specific interactions between viral and fungal proteins that work together to enhance the fungus’s natural pest-killing abilities.

Read More »

Transcriptomics Insights into Targeting CK2 Complex in Cryptococcus neoformans: Implications for Large-Scale Antifungal Virtual Screening

mycolabadmin

Scientists studied how a fungus called Cryptococcus neoformans causes serious brain infections and found that disabling a specific protein complex (CK2) could be an effective treatment strategy. Using computer analysis of genetic data, they identified three existing drugs—amphotericin B, idarubicin, and candicidin—that could potentially target and kill this dangerous fungus. This research provides a foundation for developing better treatments for cryptococcal meningitis, a life-threatening infection that kills hundreds of thousands of people annually, especially those with weakened immune systems.

Read More »

The role of Npt1 in regulating antifungal protein activity in filamentous fungi

mycolabadmin

Researchers discovered how antifungal proteins work against a dangerous fungus (Aspergillus flavus) that damages crops and produces toxins. They found that these proteins break down the fungal cell wall and then interact with an internal fungal protein called Ntp1. By understanding exactly which part of Ntp1 the antifungal proteins bind to, scientists can now develop better treatments to protect food crops from fungal diseases.

Read More »
Scroll to Top