Research Keyword: protein engineering

Computer-directed rational engineering of dioxygenase TcsAB for triclosan biodegradation under cold conditions

Scientists engineered a special enzyme called TcsAB to work better at cold temperatures, enabling it to break down triclosan, a harmful antibacterial chemical that pollutes our water. By using computer simulations and strategic mutations, they created a modified enzyme that degrades triclosan 2.5 times more efficiently at 15°C. When inserted into bacteria, this engineered enzyme helps clean up triclosan pollution in natural environments without requiring energy-intensive heating.

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Applications of Microbial Organophosphate-Degrading Enzymes to Detoxification of Organophosphorous Compounds for Medical Countermeasures against Poisoning and Environmental Remediation

Organophosphate compounds are toxic chemicals used as pesticides and banned chemical weapons that pose serious health and environmental risks. Scientists have discovered and engineered special enzymes from bacteria and other microorganisms that can break down these toxic compounds. These enzymes can be used as medical treatments to protect people exposed to organophosphates or as environmental cleanup tools to decontaminate poisoned soil and water.

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