Research Keyword: protein aggregation

Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review

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Spinocerebellar ataxia type 3 is a serious brain disease that causes movement problems and gets worse over time. Current medications help but often have unpleasant side effects. This review examined fifteen traditional Chinese herbal remedies that show promise in protecting nerve cells from damage caused by oxidative stress, a harmful chemical process in the body. These herbs work through multiple protective mechanisms and may eventually be tested in patients.

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The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks

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Reishi mushroom, used in traditional Asian medicine for centuries, contains over 400 bioactive compounds that show promise in protecting the brain from degenerative diseases like Alzheimer’s and Parkinson’s. The mushroom’s components work through multiple pathways to reduce inflammation, fight oxidative stress, and protect neurons from damage. While laboratory and animal studies show encouraging results, human clinical trials are needed to confirm its effectiveness as a treatment.

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Application Potential of Lion’s Mane Mushroom in Soy-Based Meat Analogues by High Moisture Extrusion: Physicochemical, Structural and Flavor Characteristics

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Researchers created a plant-based meat substitute using soy protein and Lion’s Mane mushroom powder processed through extrusion. Adding 20% mushroom powder created the best texture, making it more similar to real meat with visible fibers. The mushroom also improved the flavor, adding mushroom-like aromas and making the product brown better during cooking. This discovery could help make better-tasting plant-based meat alternatives for consumers.

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N-terminal oligomerization drives HDAC4 nuclear condensation and neurodevelopmental dysfunction in Drosophila

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This study reveals how a protein called HDAC4 forms clumps inside cell nuclei, which damages brain development. Researchers found that the protein’s ability to stick to itself (oligomerize) drives this clumping process. By modifying the protein to prevent self-sticking, they reduced the damage to developing brain structures, suggesting new ways to treat brain disorders linked to HDAC4 accumulation.

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