Research Keyword: primary metabolism

Genetic regulation of l-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis

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Researchers studied how magic mushrooms (Psilocybe mexicana) regulate their chemistry to produce psilocybin, the psychoactive compound. They found that when mushrooms start fruiting, they turn on genes that make tryptophan (an amino acid building block) and turn off genes that break it down, directing all the tryptophan toward psilocybin production. This coordinated genetic control ensures the mushroom has enough of this key ingredient. This knowledge could help grow these mushrooms in labs for legitimate medical research into treating depression.

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Low Temperature Enhances N-Metabolism in Paxillus involutus Mycelia In Vitro: Evidence From an Untargeted Metabolomic Study

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This study examined how a common forest fungus (Paxillus involutus) responds to cold temperatures by analyzing its chemical composition. When kept at cold temperatures like those found in spring and autumn forests, the fungus took up and used more nitrogen for making amino acids and other nitrogen compounds, even though it grew more slowly. This suggests that cold-adapted fungi have special mechanisms to acquire nutrients efficiently in cold conditions, which may be important for how they help trees survive in changing climates.

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