Research Keyword: PKS

Comparative proteomics reveals the mechanism of cyclosporine production and mycelial growth in Tolypocladium inflatum affected by different carbon sources

Scientists studied how different sugar sources (fructose versus sucrose) affect the production of cyclosporine A, an important drug used to prevent organ rejection after transplants. Using advanced protein analysis techniques, they identified which proteins were more active in each sugar environment and discovered that fructose promotes drug production while sucrose promotes fungal growth. This research could help pharmaceutical companies produce cyclosporine more efficiently by identifying key proteins to enhance.

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Complete genome analysis and antimicrobial mechanism of Bacillus velezensis GX0002980 reveals its biocontrol potential against mango anthracnose disease

Researchers discovered a beneficial bacterium called Bacillus velezensis that can prevent mango rot caused by a destructive fungus. This bacterium produces natural antimicrobial compounds that kill the disease-causing fungus without the need for harmful chemical pesticides. When applied to mangoes, it reduced disease by 52% and extended the fruits’ shelf life, offering a safe and environmentally friendly solution for protecting mangoes after harvest.

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Polyamine Induction of Secondary Metabolite Biosynthetic Genes in Fungi Is Mediated by Global Regulator LaeA and α-NAC Transcriptional Coactivator: Connection to Epigenetic Modification of Histones

Polyamines are natural compounds that act like chemical switches controlling how fungi produce useful medicines like antibiotics and statins. These molecules work by attaching to DNA and modifying histone proteins, which turns on or off the genes responsible for making pharmaceutical compounds. This research reveals that understanding polyamine control could help scientists increase antibiotic production and make plants more resistant to fungal diseases.

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