Research Keyword: phospholipase C

Transcriptome sequencing reveals Vmplc1 involved in regulating the pathogenicity of Valsa Mali under low temperature induction

Apple trees suffer from a fungal disease called Valsa canker that becomes more severe in cold weather. Scientists discovered that the fungus has a special protein called Vmplc1 that acts like a temperature sensor, telling the fungus to produce more aggressive enzymes when it’s cold. When researchers disabled this protein, the fungus lost its ability to damage apple trees during cold periods. This discovery helps explain why the disease is worse in spring and could lead to better disease management strategies.

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Phospholipase PlcH is involved in the secretion of cell wall glycoproteins and contributes to the host immune response of Aspergillus fumigatus

Researchers discovered that an enzyme called PlcH helps a dangerous mold called Aspergillus fumigatus release protective proteins into its cell wall. These proteins help the fungus survive and evade the immune system. When scientists removed the gene for PlcH, the fungus became weaker and more vulnerable to both antifungal drugs and immune cells, suggesting PlcH could be a target for new antifungal treatments.

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