Research Keyword: phenotypic identification

Spread of Antifungal-Resistant Trichophyton indotineae, United Kingdom, 2017–2024

A fungal infection called Trichophyton indotineae, which originated in Asia, is rapidly spreading throughout the United Kingdom and becoming resistant to common antifungal treatments. The infection typically starts in the groin area and can spread to other parts of the body, and many cases fail to respond to standard antifungal drugs like terbinafine. Researchers tracked 157 cases over seven years and found the fungus now accounts for over a third of all dermatophyte infections sent to the UK reference laboratory. Doctors and laboratory professionals are being urged to recognize this emerging threat and consider better diagnostic and treatment strategies.

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Clinico-mycological study of superficial mycoses and correlation with anti-fungal susceptibility among the Candida isolates in a teaching institution of Western India

This study examined fungal skin infections in 330 patients in Western India, identifying which fungi cause these infections and which antifungal drugs work best. Researchers found that Candida yeasts were especially common in nail infections while Trichophyton fungi were more common in skin infections. The antifungal drug caspofungin was most effective against Candida, while the commonly used drug fluconazole showed increasing resistance.

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Saksenaea oblongispora Rhinosinusitis in Advanced HIV: A Rare and Lethal Mucormycosis

A 32-year-old man with advanced HIV developed a severe fungal infection of his sinuses caused by a rare fungus called Saksenaea oblongispora, which typically doesn’t affect people with HIV. The patient presented with severe facial swelling that rapidly worsened, and despite doctors identifying the fungus through biopsies and lab tests, he did not receive antifungal treatment or surgery before his condition became critical. This is the first case of this particular fungal infection documented in sub-Saharan Africa and in HIV patients, highlighting how dangerous this rare infection can be and how challenging it is to diagnose quickly enough to save lives.

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Environmental sources of Cryptococcus neoformans species complex in Kampala, Uganda: A preliminary study

Researchers in Uganda identified where dangerous fungal organisms that cause meningitis live in the environment. They tested droppings from birds and chickens, and bark from eucalyptus trees. They found that a harmful fungus called Cryptococcus neoformans was present in marabou stork droppings and eucalyptus tree bark, but not in chicken droppings or another related fungus species called C. gattii. This helps explain why some people in Uganda get cryptococcal meningitis, a serious brain infection.

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