Phaeohyphomycosis – mycolab.ai

Phaeohyphomycosis caused by Rhinocladiella similis mimicking Sporotrichosis

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A 34-year-old factory worker developed multiple nodules on his hand following an injury, initially suspected to be sporotrichosis, a common fungal infection. Through laboratory testing including fungal culture and genetic sequencing, doctors identified the actual cause as a rare fungus called Rhinocladiella similis. The patient was successfully treated with antifungal medication and showed gradual improvement. This is the first case of this fungal infection reported in India.

Two Cases of Fungal Melanonychia

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Two patients developed dark pigmentation on their toenails caused by rare combinations of fungal infections. Through laboratory testing and genetic analysis, doctors identified fungi never before known to cause this type of nail discoloration. Both patients were successfully treated with an antifungal medication called efinaconazole, with complete resolution of symptoms within a few months.

Phaeoacremonium tuscanicum and Phaeoacremonium indicum sp. nov. associated with subcutaneous phaeohyphomycosis

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Researchers identified and described two rare fungal infections caused by Phaeoacremonium species in human patients. One case involved a previously unknown fungal species in humans called Phaeoacremonium indicum, discovered in an Indian transplant patient with a knee infection. Both cases were successfully treated with surgery, with one patient also receiving antifungal medication, demonstrating effective treatment approaches for these unusual infections.

Two Cases of Fungal Melanonychia

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This paper describes two unusual cases where fungal infections of the toenails caused dark pigmentation (melanonychia). The first patient had a combination of two fungi (Aspergillus hiratsukae and Trichosporon faecale) causing black nail streaks, while the second had Exophiala xenobiotica and Trichophyton interdigitale causing dark-brown discoloration. Both patients were successfully treated with an antifungal medication called efinaconazole over several months.

Rhino sinusitis caused by Lasiodiplodia theobromae in a diabetic patient

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A 56-year-old diabetic man developed a sinus infection caused by a rare fungus called Lasiodiplodia theobromae, which typically affects plants. The infection was diagnosed through laboratory testing and DNA sequencing, as traditional identification methods were inconclusive. The patient was successfully treated with a combination of sinus surgery and a six-week course of antifungal medication, showing complete recovery after one year of follow-up.

Phaeoacremonium iranianum – a new corneal pathogen

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A 66-year-old man developed a serious eye infection from a fungus called Phaeoacremonium iranianum after his eye was scratched by a leaf. This is the first reported case of this fungus causing a corneal infection. Doctors treated the infection with antifungal eye drops and surgery to remove infected tissue, and the patient’s condition improved over time, though with some permanent scarring of the cornea.

A Rare Case of Alternaria citri Keratitis Successfully Treated with Voriconazole

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A 71-year-old woodworker developed a serious eye infection caused by a rare fungus called Alternaria citri that damaged his cornea. Doctors identified the fungus using genetic testing and treated it with the antifungal drug voriconazole combined with surgery. After one year, his vision improved and the infection did not return, marking the first documented case of this particular fungal infection in humans.

Ventilator-associated pneumonia caused by a new-found opportunistic fungal pathogen—Myceliophthora heterothallica: a case report

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A 67-year-old woman suffered cardiac arrest and required a breathing machine to survive. While on the ventilator, doctors discovered an unusual fungal infection in her lungs caused by Myceliophthora heterothallica, which had never been documented as a human pathogen before. With standard bacterial antibiotics and supportive care, the patient recovered and was discharged after four weeks, suggesting this fungus may be less dangerous than related species.

Extensive and recurrent infection caused by Medicopsis romeroi in two immunocompromised patients

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This case report describes two patients with weakened immune systems who developed serious fungal skin infections caused by a rare mold called Medicopsis romeroi. Both patients underwent multiple surgeries and required extended antifungal medication treatment lasting months to years. The study demonstrates that successful treatment requires a combination approach including surgical removal of infected tissue, adjustment of immunosuppressive medications, and prolonged antifungal therapy.

Phaeoacremonium tuscanicum and Phaeoacremonium indicum sp. nov. associated with subcutaneous phaeohyphomycosis

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Researchers identified two cases of rare fungal skin infections caused by Phaeoacremonium species. One case involved a new fungal species named Phaeoacremonium indicum discovered in an Indian patient, while the second case from Australia represented the first documented human infection with P. tuscanicum. Both patients were successfully treated through surgical removal of the infected tissue, though one patient was immunocompromised from a kidney transplant. This study highlights how genetic testing helps identify rare fungal species that cause human infections.

Research Keyword: Phaeohyphomycosis