Research Keyword: pH adaptation

Adaptation strategies in haloalkaliphilic fungi: Aspergillus salinarum, Cladosporium sphaerospermum, and Penicillium camemberti

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Researchers studied three special fungi that can survive in extremely salty and alkaline environments. These fungi adapt to harsh conditions by producing more proteins, fats, and special enzymes that have antimicrobial properties. The findings suggest these fungi could be useful for cleaning contaminated soils, producing medicines, and developing new industrial products.

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Acidic pH Modulates Cell Wall and Melanization in Paracoccidioides brasiliensis, Affecting Macrophage Interaction

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A dangerous fungal infection called paracoccidioidomycosis affects people in Latin America. Researchers found that when this fungus encounters acidic conditions similar to those inside immune cells in the body, it protects itself by producing a dark pigment called melanin and changing its cell surface. These changes help the fungus hide from the immune system and reduce the ability of immune cells called macrophages to attack and destroy it.

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Acidic pH Reduces Fluconazole Susceptibility in Cryptococcus neoformans by Altering Iron Uptake and Enhancing Ergosterol Biosynthesis

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This research shows that acidic environments, like those found in inflamed tissues and inside immune cells, make the fungus Cryptococcus neoformans more resistant to the antifungal drug fluconazole. The fungus adapts to acidic conditions by using an alternative iron uptake system that increases the production of protective compounds (ergosterol) in its cell membrane. Understanding this pH-dependent resistance mechanism could help develop better treatment strategies for cryptococcal infections in patients with compromised immune systems.

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