Research Keyword: pediatric mucormycosis

Disseminated mucormycosis leading to a fatal gastrointestinal perforation in a pediatric case of EBV-associated Hemophagocytic lymphohistiocytosis

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A 12-month-old girl with a severe immune system disorder (HLH) triggered by Epstein-Barr virus developed a life-threatening fungal infection (mucormycosis) that spread throughout her digestive system. Despite aggressive treatment with multiple antifungal medications and emergency surgery, the infection caused her intestines to perforate, leading to her death. The case highlights the difficulty in recognizing fungal infections early in immunocompromised children and the need for heightened clinical awareness.

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Catastrophic Cerebral Infarctions in a Pediatric Patient with Acute Lymphoblastic Leukemia Due to Mucorales Infection

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An 11-year-old girl with leukemia undergoing chemotherapy developed a severe fungal infection called mucormycosis caused by Lichtheimia ramosa. The infection spread rapidly from her sinuses to her eyes and brain, causing multiple blood clots in brain arteries and a massive stroke within just five days. Despite emergency surgery to remove the clots, the infection had progressed too far and the patient sadly did not survive, highlighting how dangerous this fungal infection can be in children with weakened immune systems.

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