Research Keyword: pathway analysis

The molecular mechanisms through which psilocybin prevents suicide: evidence from network pharmacology and molecular docking analyses

Researchers used computer-based analysis to understand how psilocybin, a compound found in certain mushrooms, might help prevent suicide. They identified four key proteins that psilocybin interacts with and found that it works through serotonin and calcium signaling pathways in the brain, which are known to be involved in depression and suicidal behavior. While these findings are promising, more research is needed to confirm these effects in humans before psilocybin can be used clinically for suicide prevention.

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Transcriptome analysis of Ochratoxin A (OTA) producing Aspergillus westerdijkiae fc-1 under varying osmotic pressure

This research studied how salt concentration affects the production of ochratoxin A, a toxic substance produced by the fungus Aspergillus westerdijkiae that contaminates foods like coffee and grapes. Using advanced genetic analysis, scientists found that moderate salt levels (20 g/L) increase the fungus’s ability to produce this toxin by affecting specific genes. The findings help explain why OTA contamination is more common in salty foods like cured meats and suggest new ways to prevent this contamination and protect food safety.

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Comparative Study and Transcriptomic Analysis on the Antifungal Mechanism of Ag Nanoparticles and Nanowires Against Trichosporon asahii

Researchers compared two types of tiny silver particles (nanoparticles and nanowires) as potential treatments for a dangerous fungal infection caused by Trichosporon asahii. Silver nanowires were found to be more effective than nanoparticles at killing the fungus by damaging its cell membranes and disrupting its energy production. The study identified 15 key genes involved in how silver nanowires attack the fungus, suggesting these nanomaterials could become useful alternatives to traditional antifungal drugs.

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