Research Keyword: pathogenesis mechanisms

Microbial links to Alzheimer’s disease

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Researchers are investigating whether common infections from bacteria, viruses, and fungi might trigger or worsen Alzheimer’s disease. Studies show that pathogens like the bacteria that causes gum disease and certain herpes viruses can reach the brain and trigger inflammation and amyloid-beta accumulation, key features of Alzheimer’s. While the evidence is promising, scientists haven’t yet proven whether these infections cause Alzheimer’s or simply make existing disease worse.

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The dimorphic fungus Talaromyces marneffei: An opportunistic killer in Southeast Asia

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Talaromyces marneffei is a dangerous fungus found in Southeast Asian soil that people inhale, causing a serious disease called talaromycosis. The fungus is particularly deadly for people with weakened immune systems like those with advanced HIV. The fungus has evolved clever tricks to hide from and manipulate the body’s immune system, allowing it to multiply inside immune cells called macrophages.

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Global research hotspots and trends in oxidative stress-related diabetic nephropathy: a bibliometric study

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This study analyzed over 4,000 research papers published between 2014 and 2024 about how oxidative stress damages kidneys in diabetic patients. Researchers found that China and the United States lead this research field, with increasing focus on natural compounds and traditional medicines that can reduce harmful reactive oxygen species. The findings suggest future treatments for diabetic kidney disease should target oxidative stress through both conventional drugs and natural antioxidant compounds derived from plants and fungi.

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Healthcare-associated fungal infections and emerging pathogens during the COVID-19 pandemic

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During the COVID-19 pandemic, fungal infections became a major health concern, especially in hospitalized patients. Treatments for COVID-19, such as steroids and immunosuppressive drugs, weakened patients’ immune systems, making them vulnerable to serious fungal infections like those caused by Candida auris. Current antifungal medications have significant side effects and many fungi are developing resistance, so scientists are urgently seeking safer and more effective antifungal treatments.

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