Research Keyword: pain management

Psilocybin for clinical indications: A scoping review

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This comprehensive review examined over 190 research studies on psilocybin (the active compound in magic mushrooms) as a medical treatment. The research shows promise for treating depression, anxiety, substance use disorders, and chronic pain, though most studies conducted so far have been small in size. While the evidence is encouraging, researchers emphasize the need for larger, better-designed clinical trials to fully understand psilocybin’s benefits and safety profile.

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Social pain: A systematic review on interventions

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This study reviews different treatments for social pain—the emotional hurt from rejection and social exclusion. Researchers found that regular pain reliever acetaminophen, mindfulness meditation, and the psychedelic compound psilocybin can reduce social pain, while placebo pills also help when people believe they work. Interestingly, combining acetaminophen with forgiveness works better than either alone, suggesting that both physical and emotional pain may use similar brain pathways.

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A systematic review to assess the use of psilocybin in the treatment of headaches

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Researchers reviewed eight studies examining whether psilocybin, a naturally occurring psychedelic compound found in certain mushrooms, could treat various types of headaches and migraines. Most studies found that psilocybin provided clinically significant relief, with participants experiencing improvements in how often they got headaches, how intense they were, and how long they lasted. However, some users experienced side effects like hallucinations or temporary increases in anxiety, and the compound remains illegal in most countries, limiting current research.

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Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies

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Chronic pain affects millions of people and is often resistant to current treatments. This paper suggests that chronic pain emerges from interconnected biological, psychological, and social factors working together as a complex system. The authors propose that psychedelic-assisted therapies could help by breaking rigid thought and behavior patterns that maintain pain, allowing the brain and mind to reorganize in healthier ways, similar to how mindfulness meditation works but potentially more dramatically.

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