Research Keyword: p21

Exploring the Bioactive Potential of Calostoma insigne, an Endangered Culinary Puffball Mushroom, from Northeastern Thailand

This research investigated a rare, eye-shaped mushroom called Calostoma insigne that grows in Thai rainforests and is eaten by local people. Scientists confirmed traditional beliefs that the mushroom has health benefits, discovering it has antioxidant, anti-cancer, and anti-diabetic properties. The study also determined the best way to grow this mushroom in laboratories, which could help conserve the endangered species while providing a sustainable food and health resource.

Read More »

GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

As we age, brain cells called excitatory neurons undergo senescence, similar to cellular ageing. This study found that a protein called GDF11 protects these neurons from ageing. When GDF11 was removed from excitatory neurons in mice, the neurons aged faster, leading to memory problems and shorter lifespans. The research reveals that GDF11 works by blocking p21, a molecule that promotes cellular ageing.

Read More »
Scroll to Top