oxidative stress – Page 3

Biological Characteristics, Domesticated Cultivation Protocol, Antioxidant Activity, and Protective Effects against Cellular Oxidative Stress of an Underutilized Medicinal Mushroom: Fomitopsis palustris

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Researchers successfully grew and studied Fomitopsis palustris, a medicinal mushroom, in laboratory conditions. They discovered that the mushroom contains beneficial compounds that protect cells from damage caused by harmful free radicals. The polysaccharides extracted from the mushroom boosted the cells’ natural defense systems and reduced oxidative stress markers, suggesting potential health benefits for treating age-related and degenerative diseases.

The phenol-2-monooxygenase FgPhm1 regulates DON synthesis, pathogenicity and environmental stress response in Fusarium graminearum

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Researchers studied a fungal protein called FgPhm1 in a wheat-infecting fungus that produces harmful toxins called DON. By deleting this gene, they found that the fungus became unable to infect plants and produce toxins, making it less dangerous. The protein also helps the fungus handle stress conditions, and removing it makes the fungus sensitive to oxidative stress while paradoxically tolerant to phenol.

Benefits and risks of hair, skin, and nail supplements in older adults

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This article reviews popular supplements that older adults, especially women, take to improve their hair, skin, and nails. While some supplements like nicotinamide show promise for sun-damaged skin, most lack strong evidence of benefit in healthy people. Important risks include biotin interfering with heart and thyroid tests, too much zinc causing copper deficiency, and excess vitamins A and E building up to toxic levels. Doctors should talk to older patients about these supplements and help them make informed decisions based on scientific evidence rather than marketing claims.

Investigating the Neuroprotective, Hepatoprotective, and Antimicrobial Effects of Mushroom Extracts

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This study examined four types of edible mushrooms to see if they could protect against aging and fight harmful bacteria. Researchers gave mice an aging-inducing substance and then treated them with mushroom extracts. The mushrooms, particularly Lion’s Mane (Hericium erinaceus), helped prevent brain and liver damage, reduced inflammation, and showed antibacterial effects against multiple bacterial strains. These findings suggest mushrooms could be useful natural supplements to promote health and combat age-related decline.

The Effects of Iterative Freeze–Thaw Cycles on the Structure, Functionality, and Digestibility of Grifola frondosa Protein

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This research shows that freezing and thawing maitake mushroom protein in controlled cycles can significantly improve its ability to stabilize oil and water mixtures in food products. The best results occur after 2-3 cycles, which enhance both how well the protein breaks down during digestion and how effectively it works as an emulsifier in foods like sauces and dressings. This simple physical treatment method offers a sustainable way to improve mushroom protein for food manufacturing without affecting its nutritional quality.

Lentinan Alleviated PM2.5 Exposure-Induced Epithelial–Mesenchymal Transition in Pulmonary Epithelial Cells by Inhibiting the GARP/TGF-β/Smad Pathway

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Air pollution particles (PM2.5) can cause serious lung damage by triggering a process called epithelial-mesenchymal transition, where lung cells lose their protective qualities. This study found that a natural compound called lentinan, derived from shiitake mushrooms, can help prevent this harmful process by blocking a protein called GARP. The research suggests that lentinan could be a promising natural treatment for lung diseases caused by air pollution.

Nutrition and Diet in the Prevention and Management of Prostate Cancer in Mexico: A Narrative Review

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This review shows that what men eat significantly affects prostate cancer risk, with certain foods offering strong protection while others increase risk. Traditional Mexican foods like tomatoes, avocados, beans, and whole grains provide excellent protection through antioxidants and healthy fats. Making dietary changes that respect cultural preferences and fit within budgets is more likely to succeed, making food-based prevention a practical strategy for reducing Mexico’s prostate cancer burden.

Neuroprotective Effect of Mixed Mushroom Mycelia Extract on Neurotoxicity and Neuroinflammation via Regulation of ROS-Induced Oxidative Stress in PC12 and BV2 Cells

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A mixture of three medicinal mushrooms (Phellinus linteus, Ganoderma lucidum, and Inonotus obliquus) was tested for its ability to protect nerve cells from damage. The extract successfully reduced cell death in laboratory models of neurodegeneration by reducing harmful molecules called reactive oxygen species and reducing inflammation. These results suggest the mushroom extract could potentially help prevent or slow neurological diseases like Alzheimer’s.

The Potential of Naturally Derived Compounds for Treating Chronic Kidney Disease: A Review of Autophagy and Cellular Senescence

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This review explores how natural products from traditional Chinese medicine may help treat chronic kidney disease by targeting two key aging processes: autophagy (cellular self-cleaning) and cellular senescence (cellular aging). Common natural compounds like curcumin, green tea extract, and Astragalus have shown promise in protecting kidney function and reducing harmful inflammation. While these natural treatments show potential as complementary therapies alongside mainstream medicines, more clinical research is needed to confirm their effectiveness and determine optimal dosages.

Pleurotus eryngii Culture Filtrate and Aqueous Extracts Alleviate Aflatoxin B1 Synthesis

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This research demonstrates that extracts from oyster mushrooms (Pleurotus eryngii) can effectively prevent the production of aflatoxin B1, a highly toxic and cancer-causing substance produced by certain molds that contaminate crops like corn and wheat. The mushroom extracts work by inhibiting the toxin production by up to 94%, offering a natural, environmentally-friendly alternative to chemical pesticides. The study suggests that compounds in mushrooms, including special sugars and enzymes, may help protect food supplies from this dangerous contamination, which is becoming increasingly important as climate change creates more favorable conditions for mold growth.

Research Keyword: oxidative stress