Research Keyword: osteomyelitis

Epidemiology and outcomes of Candida-associated osteoarticular infections: A multicentre retrospective study from Turkey

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This study examined 73 patients in Turkey who developed bone and joint infections caused by Candida fungi over ten years. The researchers found that diabetes was very common among patients and made recovery harder, while surgery to clean out infected tissue significantly improved outcomes. Importantly, they discovered resistance to common antifungal medications was higher in certain Candida species compared to others.

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Fungal Infections – a Stealthy Enemy in Patients with Chronic Granulomatous Disease: a 28-years’ Experience from North India

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Patients with chronic granulomatous disease (CGD), a rare immune system disorder, are highly susceptible to serious fungal infections. This study of 99 patients over 28 years found that 40% developed fungal infections, mostly caused by Aspergillus fungi affecting the lungs. These infections were life-threatening, with over half the infected patients dying despite aggressive treatment with antifungal medications. Doctors need to screen for fungal infections early, even in patients without obvious symptoms, and treat infants and males more aggressively.

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Musculoskeletal Manifestations of Disseminated Fungal Infections

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Fungal infections can spread to bones and joints, causing serious complications especially in people with weakened immune systems. These infections are tricky to diagnose because their symptoms are similar to bacterial infections or other diseases. Treatment typically involves antifungal medications and sometimes surgery to remove infected tissue. Early detection and aggressive treatment are crucial for better patient outcomes.

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Odontogenic-onset mucormycosis: A case series from a tertiary care institute in North India

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This study describes five cases of a serious fungal infection called mucormycosis that started in the mouth following dental procedures like tooth extraction. All patients had uncontrolled diabetes, which made them vulnerable to this infection. The infection was treated with antifungal medications and surgery, with good recovery. The findings highlight how important it is for dentists to follow strict hygiene practices and for diabetic patients to keep their blood sugar controlled before dental work.

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Case Commentary: Successful use of olorofim for the treatment of multi-drug-resistant Lomentospora prolificans infection in a child

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A young girl contracted a dangerous drug-resistant fungal infection in her knee after an injury, which failed to respond to standard antifungal treatments. Doctors obtained special access to an experimental antifungal drug called olorofim through a compassionate use program. The child showed improvement within two weeks and was completely cured after six months of treatment with no signs of the infection returning two years later, making this the first successful case of this new drug being used in a child.

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Successful management of Lomentospora prolificans septic arthritis and osteomyelitis in an immunocompetent child: A case report

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A 3-year-old healthy child developed a serious fungal bone and joint infection in the elbow after surgery to repair a broken arm bone. The fungus, called Lomentospora prolificans, is extremely resistant to most medications and can lead to limb amputation. Doctors saved the child’s arm by combining multiple approaches: repeated surgeries to clean out infected tissue, three different antifungal medications taken together, special antibiotic-loaded bone cement placed in the elbow, and antiseptic wound washing. After six months of treatment, the infection was cured and the child could use their arm again.

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