Research Keyword: Opportunistic fungal infection

The 2025 EQUAL Pneumocystis Score—an ECMM tool to measure QUALity in Pneumocystis pneumonia management

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Pneumocystis pneumonia is a serious lung infection that affects people with weakened immune systems, including those with HIV and transplant patients. Doctors use different guidelines to diagnose and treat this infection, but these guidelines are complex and can be hard to follow consistently. Researchers created a new scoring system called the EQUAL Pneumocystis Score that helps doctors follow the best treatment recommendations by assigning points for different diagnostic tests, medications, and follow-up strategies.

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Sarocladium implicatum: an unusual agent of opportunistic infection in a COVID-19 patient

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A patient hospitalized with severe COVID-19 developed an unusual infection caused by a mold called Sarocladium implicatum, which typically affects plants. Due to weakened immune system from his illness and medications, the fungus spread to his bloodstream and lungs, causing persistent fever and a cavity in his lung. After molecular testing identified the fungus, he was treated with an antifungal medication called voriconazole, which successfully cured the infection.

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Brazilian task force for the management of mucormycosis

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Mucormycosis is a serious fungal infection that has become more common in Brazil, especially during COVID-19. This medical emergency requires rapid diagnosis through imaging and tissue sampling, combined with aggressive treatment including antifungal medications and surgery to remove infected tissue. The Brazilian government has made these powerful antifungal drugs more available to improve patient survival and reduce the severe complications of this dangerous infection.

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Disseminated Scytalidium philadelphianum infection in a Belgian Malinois

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A Belgian Malinois dog developed a serious fungal infection caused by Scytalidium philadelphianum, a rare mold, that affected the spine and eventually the brain. The infection was diagnosed through imaging, fluid samples, and fungal culture from the dog’s urine and spine tissue. Despite treatment with multiple antifungal medications over seven months, the dog’s condition worsened with seizures and nerve damage, leading to euthanasia. This case marks the first documented instance of this particular fungal species causing widespread disease in animals.

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Sarocladium implicatum: an unusual agent of opportunistic infection in a COVID-19 patient

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A 64-year-old man hospitalized with COVID-19 developed a serious fungal infection from Sarocladium implicatum, an unusual fungus rarely found in humans. The infection appeared in his bloodstream and lungs while his immune system was severely weakened by the virus and medications. Doctors identified the fungus using genetic testing and successfully treated him with voriconazole antifungal medication. This case highlights how COVID-19 patients in intensive care are vulnerable to rare opportunistic infections that require specialized laboratory testing to identify and treat.

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Evaluation of Antifungal Activity Against Candida albicans Isolates From HIV-Positive Patients with Oral Candidiasis in a Major Referral Hospital, West Java, Indonesia

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Researchers in West Java, Indonesia studied fungal infections in the mouths of HIV-positive patients to understand which antifungals work best. They found that a common fungal species called Candida albicans was present in all patients tested, though some resistant strains were discovered. The study showed that certain antifungal medications like voriconazole worked better than others, highlighting the importance of testing which specific medications will be effective for each patient rather than guessing.

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Disseminated Lichtheimia ramosa infection in a Japanese Black calf

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A young calf developed a serious fungal infection caused by Lichtheimia ramosa despite treatment with multiple antibiotics. The calf had an underdeveloped thymus gland, making it vulnerable to infections. The fungus spread throughout the calf’s body, affecting the liver and digestive system. This case highlights how prolonged antibiotic use and weakened immunity can allow dangerous fungi to flourish.

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