Research Keyword: Nonribosomal peptides

Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

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This review explains how scientists use metabolomics—a technique that identifies all chemical compounds in organisms—to understand how fungi cause disease and resist medicines. Fungi produce many different chemicals that help them attack our bodies and survive treatments, but these same chemicals could also be used to create new medicines. By studying these fungal chemicals, researchers can develop better antifungal drugs and understand how fungi manage to evade our immune system.

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Deletion of bZIP Transcription Factor PratfA Reveals Specialized Metabolites Potentially Regulating Stress Response in Penicillium raistrickii

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Scientists discovered that a protein called PratfA controls the production of protective compounds in a fungus (Penicillium raistrickii) that help it survive stress. By removing this protein, they found two new natural products, including one with an unusual structure. The fungus without PratfA became very sensitive to oxidative stress and couldn’t survive well, showing that this protein is important for both making protective compounds and surviving harsh conditions.

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Bacillus velezensis CNPMS-22 as biocontrol agent of pathogenic fungi and plant growth promoter

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This research demonstrates that a beneficial bacterium called Bacillus velezensis CNPMS-22 can effectively protect maize plants from fungal diseases caused by Fusarium verticillioides. When used to treat seeds before planting, this bacterium reduced disease symptoms and increased crop yield to levels comparable with chemical fungicides. The bacteria produces natural compounds that kill harmful fungi and promote plant growth, offering a safer and more sustainable alternative to chemical pesticides.

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