Research Keyword: nociception

Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain

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Researchers found that psilocybin, the active ingredient in magic mushrooms, significantly reduced chronic pain in mice through activation of specific serotonin receptors. The effects lasted for up to two weeks after a single dose, suggesting lasting changes in how the nervous system processes pain. This study suggests psilocybin could be a promising new treatment for chronic pain conditions like neuropathy and inflammation.

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Functional relationship between peripheral thermosensation and behavioral thermoregulation

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This review explains how your body senses temperature through specialized proteins called TRP channels, which detect hot and cold stimuli. These temperature-sensing proteins help you and other animals regulate body temperature by triggering behaviors like seeking warmth or coolness. Importantly, the review shows that the fatty acid composition of cell membranes can fine-tune how sensitive these temperature sensors are, offering insights into how organisms adapt to different thermal environments.

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