Research Keyword: Neutrophil function

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

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This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous yeast infections caused by Candida albicans. When this protein is missing from immune cells, mice become much more susceptible to severe fungal infections. The study found that PTP1B helps immune cells called macrophages and neutrophils kill fungi effectively, and when it’s absent, these immune cells work poorly. This discovery suggests that targeting PTP1B could be a new way to help patients fight off serious fungal infections.

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BTK drives neutrophil activation for sterilizing antifungal immunity

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BTK is a protein that helps neutrophils (immune cells) fight fungal infections, particularly Aspergillus fumigatus. A cancer drug called ibrutinib blocks BTK, which weakens neutrophil antifungal responses and increases the risk of serious fungal infections. The study found that GM-CSF may help restore some immune function in patients taking BTK-blocking drugs, offering a potential strategy to prevent these dangerous infections.

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Diagnostic Approaches to Invasive Candidiasis: Challenges and New Perspectives

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Invasive candidiasis is a dangerous fungal infection affecting critically ill hospital patients. Current testing methods like blood cultures are slow and unreliable, so doctors are developing faster tests using DNA detection and biomarkers. A combination of new diagnostic tools and prompt treatment with antifungal medications is essential to improve survival rates and reduce complications from this serious infection.

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