neutropenia – mycolab.ai

Endogenous Endophthalmitis: An underestimated serious complication in patients with disseminated fusariosis

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An 18-year-old cancer patient undergoing chemotherapy developed a serious infection with Fusarium, a mold that spread throughout his body including to his eyes, causing vision problems. Doctors treated him with a combination of antifungal medications given both systemically and directly injected into his eyes. Although the infection was controlled and his life was saved, he lost most of his vision in both eyes but was able to keep them rather than requiring removal.

Fungal Pneumonia and Severe Neutropenia: Risk Factors for Increased 90 Day Mortality

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This study examined 39 cancer patients with severe fungal lung infections treated at a major cancer center. Patients who received antifungal treatment within 7 days and started with a specific drug called liposomal amphotericin B had better survival rates at 90 days. The research suggests that quick diagnosis and prompt treatment initiation are critical for improving survival in immunocompromised patients with fungal pneumonia.

Risk factors for invasive fungal infections in adult patients with hematological malignancies and/or stem cell transplant: a systematic review and meta-analysis

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This comprehensive study analyzed multiple research papers to identify which patients with blood cancers or stem cell transplants are most likely to develop serious fungal infections. The researchers found that patients who previously had a stem cell transplant, those taking corticosteroids, and those with low white blood cell counts face the highest risks. Importantly, the study showed that using antifungal medications as a preventive treatment significantly reduces infection risk in these vulnerable patients.

Sarocladium implicatum: an unusual agent of opportunistic infection in a COVID-19 patient

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A patient hospitalized with severe COVID-19 developed an unusual infection caused by a mold called Sarocladium implicatum, which typically affects plants. Due to weakened immune system from his illness and medications, the fungus spread to his bloodstream and lungs, causing persistent fever and a cavity in his lung. After molecular testing identified the fungus, he was treated with an antifungal medication called voriconazole, which successfully cured the infection.

Invasive Trichoderma longibrachiatum breakthrough infection in a hematology patient

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A 61-year-old woman with blood cancer developed a severe and unusual double fungal infection caused by two mold species while being treated for a known fungal infection. Despite receiving multiple antifungal medications, her condition worsened and she ultimately died from multiple organ failure. The case is important because it demonstrates how Trichoderma fungi are becoming dangerous pathogens in very sick, immunocompromised patients, and a new drug called olorofim showed promising activity against this infection in laboratory tests.

Endogenous Endophthalmitis: An underestimated serious complication in patients with disseminated fusariosis

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An 18-year-old leukemia patient developed a serious fungal eye infection from Fusarium during cancer treatment. The infection spread through the bloodstream to both eyes, causing serious inflammation and vision loss. Doctors treated it with multiple antifungal medications injected directly into the eyes along with systemic medication, which controlled the infection but unfortunately the patient’s vision was significantly affected. This case highlights how rare but serious eye infections can occur in cancer patients with weakened immune systems.

Magnusiomyces capitatus bloodstream infection in a patient with acute monocytic leukemia: A rare case report

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A 26-year-old patient with acute leukemia developed a serious fungal blood infection caused by Magnusiomyces capitatus, a rare organism found in environmental sources. The infection was confirmed using advanced molecular techniques and showed resistance to common antifungal drugs but responded to amphotericin B treatment. This case highlights how important it is for doctors to consider unusual fungi in severely immunocompromised patients and to use modern diagnostic methods for accurate identification and tailored treatment.

Cellular Composition of Bronchoalveolar Lavage Fluid in Patients with Hematologic Malignancies and Invasive Pulmonary Aspergillosis: Significant Associations with Peripheral Blood Cell Counts

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Researchers studied lung fluid samples from cancer patients with a serious fungal lung infection called invasive pulmonary aspergillosis. They found that blood cell counts in the lungs correlated with blood cell counts overall, but surprisingly, the cell composition in lung fluid did not predict patient survival. The study highlights that doctors need better ways to assess the lung’s immune response to this serious fungal infection beyond just counting cells.

Masquerading Yeast: A Case Report of Lomentospora prolificans Fungemia With a Diagnostic Twist

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This case describes a patient with blood cancer who developed a rare and deadly mold infection called Lomentospora prolificans while receiving cancer treatment. The infection was difficult to diagnose initially because the fungal structures looked similar to yeast under the microscope, and a molecular test gave a false positive result for a different fungus. Unfortunately, the infection was resistant to all available antifungal medications and the patient died.

Candidemia due to Candida lambica in a neutropenic oncology patient: A rare case report

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A 56-year-old cancer patient developed a serious bloodstream infection caused by a rare yeast called Candida lambica despite taking antifungal medications. Doctors identified the infection using genetic sequencing and found that the organism was sensitive to a different antifungal drug called voriconazole. After switching medications and removing the patient’s central line, the infection cleared up. This case demonstrates the importance of accurately identifying fungal infections and testing which medications work best against them.

Research Keyword: neutropenia