neuroinflammation – Page 2

Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia

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Schizophrenia involves excessive loss of connections between brain cells in areas responsible for emotion and thinking, leading to negative symptoms and cognitive problems. Research shows that small doses of psychedelics like psilocybin can promote the growth of new brain connections and reduce inflammation. The authors suggest that microdosing psychedelics alongside standard treatments might help restore these lost connections and improve symptoms that don’t respond well to current medications.

A comprehensive overview of the effects of probiotics, prebiotics and synbiotics on the gut-brain axis

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This comprehensive review examines how probiotics (beneficial live bacteria), prebiotics (food for beneficial bacteria), and synbiotics (combinations of both) can influence communication between the gut and brain. These interventions can produce beneficial compounds like GABA and serotonin, strengthen the gut barrier, and reduce inflammation, potentially helping with mood, anxiety, cognition, and various digestive disorders. However, effects vary greatly depending on the specific strain used, dosage, and individual differences in gut bacteria, and more large-scale studies are needed to confirm long-term clinical benefits.

Neuroprotective Effect of Mixed Mushroom Mycelia Extract on Neurotoxicity and Neuroinflammation via Regulation of ROS-Induced Oxidative Stress in PC12 and BV2 Cells

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A mixture of three medicinal mushrooms (Phellinus linteus, Ganoderma lucidum, and Inonotus obliquus) was tested for its ability to protect nerve cells from damage. The extract successfully reduced cell death in laboratory models of neurodegeneration by reducing harmful molecules called reactive oxygen species and reducing inflammation. These results suggest the mushroom extract could potentially help prevent or slow neurological diseases like Alzheimer’s.

Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease

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Mushrooms contain special compounds that may help protect the brain from Alzheimer’s disease. Research shows that eating mushrooms regularly could reduce the risk of memory problems and cognitive decline in older adults. These compounds work by reducing brain inflammation, protecting nerve cells, and helping the brain clear out harmful proteins. While these findings are promising, more human studies are needed to confirm how effective mushrooms are as an Alzheimer’s treatment.

The Immune Mind: Linking Dietary Patterns, Microbiota, and Psychological Health

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This review shows that what we eat significantly affects our mental health through our gut bacteria and immune system. Mediterranean-style diets rich in vegetables, whole grains, and healthy fats can help reduce depression and anxiety symptoms. Conversely, ultra-processed foods with added sugars and artificial ingredients increase the risk of mental health problems. Specific probiotic supplements may also provide modest benefits for mood by promoting beneficial gut bacteria.

The Effectiveness of Microdosed Psilocybin in the Treatment of Neuropsychiatric Lyme Disease: A Case Study

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A 70-year-old man suffering from severe depression and anxiety caused by chronic Lyme disease and related tick-borne infections found relief after taking small doses of psilocybin mushrooms three times a week. Within days of starting treatment, his mood improved dramatically, and he remained symptom-free for two years. This case suggests that psilocybin’s ability to reduce inflammation in the brain may help patients with infectious-caused psychiatric conditions who cannot tolerate standard medications.

Antioxidative Activities of Micronized Solid-State Cultivated Hericium erinaceus Rich in Erinacine A against MPTP-Induced Damages

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Researchers tested a processed form of Lion’s mane mushroom (Hericium erinaceus) to see if it could protect against Parkinson’s disease-like damage in mice. The mushroom mycelium was specially processed to break down cell walls and increase its effectiveness. When given to mice exposed to a Parkinson’s-causing toxin, the mushroom treatment restored dopamine levels and reduced harmful oxidative stress in the brain and liver in a dose-dependent manner.

Neuroprotective Effects of Mushroom Biomass Digestive Fractions and Gut Microbiota Metabolites in Microglial and Caenorhabditis elegans Models of Neurodegeneration

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This study tested whether common and medicinal mushrooms could protect against Alzheimer’s disease by reducing harmful reactive oxygen species in brain cells. Researchers tested three mushroom types using digestive simulation to see what the body could absorb, plus key compounds made by gut bacteria. The mushroom extracts and certain bacterial metabolites successfully reduced cellular damage markers and improved behavior in disease-model worms, suggesting mushroom-rich diets may help prevent neurodegeneration.

The Effect of Combined Treatment of Psilocybin and Eugenol on Lipopolysaccharide-Induced Brain Inflammation in Mice

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This study tested whether psilocybin (an active compound from magic mushrooms) combined with eugenol (a natural compound from cloves) could reduce brain inflammation in mice. Researchers gave mice a substance that triggers inflammation in the brain and then treated them with these compounds before or after the inflammation started. The combination treatment, especially at a 1:50 ratio of psilocybin to eugenol, significantly reduced multiple inflammatory markers in the brain, suggesting this combination could potentially be helpful for treating brain inflammation-related conditions.

Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation

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Researchers found that sporoderm-removed Ganoderma lucidum spore powder (S-GLSP) protects against Alzheimer’s disease by reducing brain inflammation. The supplement works by shifting immune cells in the brain called microglia from a harmful pro-inflammatory state to a protective anti-inflammatory state. This is accomplished by blocking the NLRP3 inflammasome, a key trigger of brain inflammation. In animal and cell studies, S-GLSP improved memory, reduced neuronal damage, and decreased harmful tau protein accumulation.

Research Keyword: neuroinflammation