Research Keyword: neuroimaging biomarkers

Improved mental health outcomes and normalised spontaneous EEG activity in veterans reporting a history of traumatic brain injuries following participation in a psilocybin retreat

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Researchers studied how psilocybin mushrooms given in a retreat setting could help military veterans with traumatic brain injuries who also experienced mental health problems like PTSD and depression. Veterans participated in guided psilocybin ceremonies and showed significant improvements in depression, anxiety, and overall quality of life, along with positive changes in their brain activity patterns measured by EEG. The study suggests that psilocybin retreats may be a promising therapeutic approach for this vulnerable population and supports the need for larger research studies.

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Associations Between Escitalopram and Psilocybin Therapy and Brain Resting-State Functional Connectivity in Major Depressive Disorder

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This study compared how two depression treatments—a common antidepressant called escitalopram and psilocybin therapy—affect brain connectivity and depression symptoms. Both treatments reduced feelings of lacking pleasure and impulsive behaviors in depressed patients. The research found that while both worked, they affected different parts of the brain’s reward system in distinct ways, suggesting they may work through different mechanisms.

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Study protocol for ‘Psilocybin in patients with fibromyalgia: brain biomarkers of action’

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Researchers are testing whether psilocybin (the active compound in magic mushrooms) combined with therapeutic support can help people with fibromyalgia, a chronic pain condition. The study will measure brain activity using EEG and brain imaging to understand how psilocybin might reduce pain and improve mental health. Twenty patients will receive guided psilocybin sessions over eight weeks while researchers track changes in brain function and pain levels.

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