Research Keyword: neglected tropical disease

Sandalwood Sesquiterpene (Z)-α-Santalol Exhibits In Vivo Efficacy Against Madurella mycetomatis in Galleria mellonella Larvae

mycolabadmin

Researchers tested sandalwood compounds against a fungal infection that causes a tropical disease called eumycetoma. Using a laboratory model with wax moth larvae infected with the fungus, they found that a specific compound called (Z)-α-santalol significantly extended the survival of infected larvae. This compound was more effective than current antifungal drugs and showed promise as a potential new treatment for this neglected tropical disease.

Read More »

Madurella tropicana and Madurella pseudomycetomatis identified as new causative agents of black grain eumycetoma in Senegal

mycolabadmin

This case report describes two patients in Senegal with a serious fungal infection called eumycetoma caused by previously unidentified fungal species. Using modern DNA sequencing methods, researchers identified the infections as being caused by Madurella tropicana and Madurella pseudomycetomatis, rather than the previously known Madurella mycetomatis. One patient treated with the antifungal drug itraconazole showed good improvement, highlighting the importance of accurate identification for proper treatment.

Read More »

Protoplast-mediated transformation of Madurella mycetomatis using hygromycin resistance as a selection marker

mycolabadmin

Scientists have successfully developed a genetic engineering method for Madurella mycetomatis, the fungus that causes mycetoma, a serious tropical disease. They used a technique to remove the fungal cell wall and insert genes into the cells, creating strains that produce green fluorescent protein (GFP). This breakthrough enables researchers to better understand how this fungus causes disease and to develop new treatments.

Read More »
Scroll to Top