A 46-year-old man developed a severe fungal infection of his thigh caused by Basidiobolus ranarum, a rare fungus found in soil and animal feces. The infection worsened with secondary bacterial contamination, leading to tissue death and eventually requiring amputation. Doctors successfully treated the infection using a combination approach: antifungal medications (voriconazole and potassium iodide), antibiotics, and multiple surgical cleanings, though earlier treatment would have saved his limb.