nanoparticles – Page 3

Assessment of the Antitumor Activity of Green Biosynthesized Zinc Nanoparticles as Therapeutic Agent Against Renal Cancer in Rats

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Researchers created tiny zinc nanoparticles using an edible white mushroom through an environmentally friendly process. When tested in rats with kidney cancer, these nanoparticles significantly reduced tumor markers, protected kidney cells from oxidative damage, and triggered cancer cell death. The treatment improved kidney function and showed no toxic effects, suggesting it could be a promising new therapy for kidney cancer.

Conjugation of a Cryptococcus neoformans-derived metalloprotease to antifungal-loaded PLGA nanoparticles treats neural cryptococcosis in an in vitro model

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Researchers developed tiny nanoparticle carriers coated with a fungal enzyme that helps them cross the protective barrier around the brain. These particles were loaded with an antifungal drug to treat brain infections caused by Cryptococcus neoformans. In laboratory tests, the Mpr1-coated particles successfully penetrated the blood-brain barrier better than regular nanoparticles and were more effective at killing the fungal cells.

Green Synthesized Copper-Oxide Nanoparticles Exhibit Antifungal Activity Against Botrytis cinerea, the Causal Agent of the Gray Mold Disease

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Scientists developed tiny copper oxide particles using fungi to create a natural fungicide that fights gray mold, a disease that damages grapes and other crops worldwide. These bio-based nanoparticles work better than conventional copper fungicides, offering farmers a more environmentally friendly option. However, the particles showed some toxicity to human cells in laboratory tests, suggesting they need careful handling before field use.

Encapsulation of progesterone in reishi mushroom composite for optimized hormone replacement and targeted anticancer therapy

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Researchers created a new treatment by combining progesterone (a hormone) with reishi mushroom powder to make it work better in the body. The mushroom acts like a protective wrapper that slowly releases the hormone, making it more effective for treating menopausal symptoms and fighting breast cancer cells. The combination also fights harmful bacteria and fungi while remaining stable during storage. This approach combines traditional medicine with modern pharmaceutical science.

Immunomodulatory natural polysaccharide-based nanoparticles for the treatment of neurodegenerative diseases

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Scientists are developing tiny particles made from natural sugar-based compounds that can deliver medicine to the brain while reducing inflammation caused by neurodegenerative diseases like Alzheimer’s and Parkinson’s. These nanoparticles are special because they can cross the protective barrier surrounding the brain and carry therapeutic compounds directly to where they’re needed. The natural polysaccharides used to make these particles have built-in anti-inflammatory properties, making them safer and more effective than traditional approaches. This innovative technology shows promise for treating currently difficult-to-manage brain diseases.

Chlorophyllum molybdites-synthesized manganese oxide nanoparticles (MnO-NPs): morphology, biocompatibility, and anticancer properties against liver cancer (HepG2) cell line

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Researchers successfully created tiny manganese oxide particles using a wild mushroom called Chlorophyllum molybdites through an environmentally friendly process. These nanoparticles showed strong cancer-fighting ability against liver cancer cells and were effective against a parasite that causes leishmaniasis. The particles were safe for human use with minimal damage to healthy blood cells, making them promising candidates for developing new cancer and parasitic disease treatments.

Antifungal activity of zinc oxide nanoparticles (ZnO NPs) on Fusarium equiseti phytopathogen isolated from tomato plant in Nepal

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Researchers in Nepal isolated a fungus called Fusarium equiseti that damages tomato plants and created tiny zinc oxide particles from tea leaves to fight it. These nanoparticles successfully stopped the fungus from growing, reducing its growth by up to 85%. This discovery offers farmers an environmentally friendly alternative to chemical fungicides that harm the environment and create resistant fungi.

Design and Evaluation of a Inonotus obliquus–AgNP–Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential

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Researchers studied Chaga mushroom from Romania and developed new ways to package and deliver its beneficial compounds using silver nanoparticles and a food-safe ingredient called maltodextrin. These new delivery systems were designed to work better in the body by improving how well the mushroom’s active ingredients dissolve and stay stable. Testing showed these enhanced formulations were very effective at fighting bacteria, protecting cells from damage, and killing cancer cells.

Research Keyword: nanoparticles