A 61-year-old man with a prosthetic aortic valve developed a rare fungal infection caused by Scopulariopsis brevicaulis, a mold usually associated with nail infections. The infection spread throughout his body, causing multiple strokes and aneurysms that required emergency surgery and treatment with various antifungal medications. This case highlights the serious complications that can occur when this typically harmless fungus invades the heart and demonstrates the challenges doctors face in treating such rare infections, as the fungus was resistant to many common antifungal drugs.