Research Keyword: mycosis treatment

Anticancer drugs targeting topoisomerase II for antifungal treatment

Researchers found that several anticancer drugs commonly used to treat human cancers can also effectively kill fungal infections, especially resistant strains of Candida. The most promising drug, idarubicin, works by targeting an essential enzyme in fungi called topoisomerase II, causing DNA damage and cell death. This discovery suggests a new strategy for treating serious fungal infections by repurposing existing cancer medications, particularly for patients with drug-resistant infections.

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A Case of Superficial Mycoses in a Patient with Systemic Lupus Erythematosus

A 52-year-old woman with lupus developed severe fungal skin infections that were initially mistaken for worsening lupus symptoms. Her condition improved after 6 months of treatment with two antifungal medications (terbinafine and itraconazole). This case reminds doctors that patients taking immunosuppressive medications for lupus are at high risk for fungal infections, which can be misdiagnosed as lupus flares.

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Discovery of novel targets for important human and plant fungal pathogens via an automated computational pipeline HitList

Scientists developed a computer program called HitList that searches through fungal genes to find new targets for antifungal medicines. The program identifies proteins that are unique to harmful fungi and missing from humans and plants, making them ideal drug targets. The study found several promising new protein targets that could lead to development of more effective antifungal drugs to treat both human fungal infections and crop diseases caused by fungi.

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