Research Keyword: multivariate analysis

Metabolite Profiles and Biological Activities of Different Phenotypes of Beech Mushrooms (Hypsizygus marmoreus)

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This study compared white and brown varieties of beech mushrooms, which are popular edible mushrooms in South Korea. Brown beech mushrooms were found to have higher levels of beneficial compounds called phenolics, which give them a more bitter taste and brown color. The research showed that brown mushrooms have stronger health-promoting properties, including better abilities to fight bacteria, reduce inflammation, and combat oxidative stress, making them potentially more valuable as functional foods for health and nutrition.

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Exploring Psilocybe spp. mycelium and fruiting body chemistry for potential therapeutic compounds

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This study analyzed the chemical composition of ‘magic mushrooms’ (Psilocybe) at different growth stages—liquid cultures, grain cultures, and mature fruiting bodies. Using advanced laboratory techniques, researchers found that fruiting bodies contain the highest levels of psilocybin (the psychoactive compound), while mycelium contains unique beneficial compounds like alpha-glycerylphosphorylcholine that may have therapeutic value without strong psychedelic effects. The findings suggest that Psilocybe mycelium could be developed as a non-intoxicating health supplement with potential therapeutic applications.

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Exo-metabolome profiling of soybean endophytes: a road map of antagonism against Fusarium oxysporum

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Scientists discovered that certain beneficial bacteria living inside soybean roots can protect the plant from a harmful fungus that causes root rot and reduces crop yield. By analyzing the chemical compounds these bacteria produce, researchers identified specific antifungal substances that kill or inhibit the pathogenic fungus. These findings suggest that instead of using harmful chemical fungicides, farmers could use these beneficial bacteria as a natural, environmentally-friendly way to protect soybean crops and improve agricultural sustainability.

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Exploring Psilocybe spp. mycelium and fruiting body chemistry for potential therapeutic compounds

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This study compared the chemical makeup of psilocybin mushroom mycelium (the root-like growth) versus fruiting bodies (the mushrooms themselves) to understand their different therapeutic potential. While fruiting bodies contain much higher levels of psilocybin, the psychoactive compound, mycelium accumulates other beneficial compounds like α-GPC that may enhance cognition and motor function without strong psychedelic effects. This research suggests that mushroom mycelium could be developed as a non-intoxicating therapeutic alternative with its own unique health benefits.

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Mass Spectrometry-Based Untargeted Metabolomics and α-Glucosidase Inhibitory Activity of Lingzhi (Ganoderma lingzhi) During the Developmental Stages

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Scientists studied how the medicinal mushroom Lingzhi changes chemically as it grows from mycelium through various stages to mature fruiting bodies. They found that the mushroom contains many beneficial compounds, including special molecules called triterpenoids, that help block α-glucosidase, an enzyme involved in blood sugar control. Interestingly, the immature mushroom stage showed the strongest anti-diabetic activity, suggesting farmers should harvest at specific times depending on desired health benefits rather than always waiting for full maturity.

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Incidence And Risk Factors for Invasive Fungal Infections in Pre-Transplant and Transplant-Ineligible Multiple Myeloma in the U.S.: A Claims Analysis (2017-2021)

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This study examined fungal infections in patients with multiple myeloma who were not eligible for or preparing for stem cell transplants. Researchers found that 6% of these patients developed invasive fungal infections, with yeast infections being the most common type. The risk of these infections was significantly higher in patients taking dexamethasone (a steroid) or those with low white blood cell counts and those receiving multiple cancer therapies.

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Unveiling the Substrate-Dependent Dynamics of Mycotoxin Production in Fusarium verticillioides Using an OSMAC-Metabolomics Approach

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Researchers studied how different growing conditions affect the production of harmful toxins by a fungus called Fusarium verticillioides that contaminates crops. Using advanced chemical analysis techniques, they found that the type of growth medium and time of incubation significantly influenced which toxins the fungus produced and in what amounts. Growing the fungus on corn-based medium produced different toxins than growing it on barley-based medium. These findings can help develop better strategies to prevent mycotoxin contamination in food and animal feed.

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