Research Keyword: multidrug resistance

The Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer Cells: A Systematic Review

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This systematic review examines how mushroom extracts can make chemotherapy more effective at treating cancer, particularly by helping overcome cancer cells’ resistance to drugs. Researchers found that various mushroom species contain compounds that work together with chemotherapy drugs to kill cancer cells more effectively through different cellular mechanisms. The results suggest mushroom extracts could be a promising natural complement to conventional cancer treatments, though more research is needed before they can be used clinically.

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Antibiotic Resistance Genes in Agricultural Soils: A Comprehensive Review of the Hidden Crisis and Exploring Control Strategies

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Antibiotics used in farming and medicine are creating resistant bacteria that accumulate in soil, threatening food safety and human health through the food chain. This review explains how these resistant genes spread through soil microorganisms and presents practical solutions including special soil treatments, chemical processes, and beneficial microorganisms to reduce the problem. The authors emphasize the need for stricter regulations on antibiotic use in agriculture and better management of farm manure to protect both soil health and public health.

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Current Uses of Mushrooms in Cancer Treatment and Their Anticancer Mechanisms

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This comprehensive review examines how medicinal mushrooms can help treat cancer. Certain mushroom species and their compounds, particularly polysaccharides, can boost the immune system to fight cancer cells, reduce chemotherapy side effects, and overcome drug resistance. Multiple mushrooms are currently in clinical trials showing promise in improving cancer patient outcomes when used alongside conventional treatments.

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Endophytic fungi isolated from Vietnamese nut grass (Cyperus rotundus L. Cyperaceae) – A promising solution to mitigate the prime phenomenon of antibiotic resistance

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Scientists discovered seven types of fungi living inside nut grass plants that can fight dangerous bacteria, including those resistant to current antibiotics. These fungi showed strong ability to kill drug-resistant staph bacteria and other serious pathogens. The findings suggest that these naturally-occurring fungi could be developed into new antibiotics to treat infections that currently have limited treatment options.

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Changing Climate, Changing Candida: Environmental and Social Pressures on Invasive Candidiasis and Antifungal Resistance in Latin America

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Invasive fungal infections caused by Candida yeasts are becoming more serious in Latin America, with drug-resistant strains spreading rapidly in hospitals. The problem is worsened by climate change and overuse of antifungal medicines in agriculture, which help resistant fungi survive and spread. Many hospitals in the region lack modern diagnostic tools to quickly identify the specific type of infection, delaying treatment. The authors recommend a comprehensive approach combining better environmental monitoring, smarter use of antifungal drugs, improved diagnostic access, and coordinated public health efforts across the region.

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Epidemiology of Candidemia, Candiduria and Emerging Candidozyma (Candida) auris Across Gulf Cooperative Council Countries and Yemen in the Arabian Peninsula

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This comprehensive review examines fungal bloodstream and urinary tract infections caused by Candida species across Middle Eastern countries. The study shows that while Candida albicans remains common, dangerous antibiotic-resistant strains like Candidozyma auris are increasingly appearing in hospitals. The research highlights that better diagnostic tools and infection prevention practices are urgently needed in the region to protect patients and reduce deaths from these serious infections.

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Olorofim activity against multidrug-resistant Fusarium unveils intra-species and inter-species variability

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Researchers tested a new antifungal drug called olorofim against 253 different Fusarium fungi that infect humans. Fusarium is particularly dangerous for people with weakened immune systems and resists most common antifungals. The study found that olorofim works, but its effectiveness varies significantly depending on which type of Fusarium is present. While these lab results are promising, additional testing in animal models is needed before it can be used clinically.

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