mucormycosis – Page 2

A case report of Saksenaea vasiformis mucormycosis infection of a lower segment caesarean section wound

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A young woman developed a rare fungal infection (mucormycosis) in her caesarean section wound seven days after surgery. Despite initial antibiotic treatment, she required multiple surgical debridement procedures combined with antifungal medications to eliminate the infection. The surgical team successfully reconstructed her abdominal wall using specialized mesh and skin grafting techniques, resulting in complete healing.

De novo genome sequencing and comparative analyses of the clinically relevant species Mucor ardhlaengiktus, Mucor circinelloides, Mucor griseocyanus, and Mucor janssenii

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Scientists have sequenced and analyzed the complete genomes of four species of Mucor fungus that cause serious infections in humans. Using advanced long-read sequencing technology, they created high-quality genetic blueprints for these organisms, which will help doctors better identify which Mucor species is causing infections and enable faster diagnosis and treatment of these dangerous fungal infections.

Invasive nasal and paranasal mucormycosis in a patient with severe dengue fever and multiple risk factors: A case report and literature review

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A 50-year-old woman in Vietnam developed a rare and deadly fungal infection called mucormycosis while recovering from dengue fever. She had weakened immunity from taking steroids for other conditions and from the dengue virus itself. The infection caused black, dead tissue to rapidly spread in her nose and around her eye. Despite treatment with antifungal medications, the infection progressed, and she died within days. The case shows how important it is to watch for dangerous opportunistic infections in dengue patients, especially those already dealing with weakened immune systems.

The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis

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This study evaluated how well PCR blood tests and tissue samples can diagnose a serious fungal infection called mucormycosis. Researchers analyzed 30 previous studies and found that PCR testing works very well, especially on respiratory fluid samples. Blood tests showed good accuracy too and could be useful for screening high-risk patients without requiring invasive procedures. The findings suggest PCR should become a standard diagnostic method for this difficult-to-diagnose infection.

The In vitro Effect of Nanoliposomal Amphotericin B Against Rhizopus arrhizus Isolated From COVID-19-Associated Mucormycosis Patients

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Scientists tested a new nano-formulation of the antifungal drug amphotericin B against a dangerous fungus (Rhizopus arrhizus) that infected COVID-19 patients with mucormycosis. The nanoliposomal version of the drug worked much better than regular amphotericin B and other antifungal medications currently used, showing much lower concentrations needed to kill the fungus. This research suggests the new nano-formulation could be a more effective treatment option for patients with this serious COVID-19 related fungal infection.

A prospective, multicenter study of invasive fungal disease caused by molds in children and adults in Chile

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Researchers in Chile studied serious mold infections in 176 hospitalized patients (adults and children) over two years. They found that aspergillosis (a lung infection caused by Aspergillus mold) was the most common, especially in patients whose immune systems were compromised by cancer, transplants, or medications. Interestingly, nearly 40% of cases also involved COVID-19 infection. Although almost all patients received antifungal medications, survival rates were concerning, with about one-third of patients still alive after six months.

Saksenaea oblongispora Rhinosinusitis in Advanced HIV: A Rare and Lethal Mucormycosis

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A 32-year-old man with advanced HIV developed a severe fungal infection of his sinuses caused by a rare fungus called Saksenaea oblongispora, which typically doesn’t affect people with HIV. The patient presented with severe facial swelling that rapidly worsened, and despite doctors identifying the fungus through biopsies and lab tests, he did not receive antifungal treatment or surgery before his condition became critical. This is the first case of this particular fungal infection documented in sub-Saharan Africa and in HIV patients, highlighting how dangerous this rare infection can be and how challenging it is to diagnose quickly enough to save lives.

Pathogenic mucorales: Deciphering their cell wall polysaccharidome and immunostimulatory potential

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Mucormycosis is a serious fungal infection that primarily affects people with weak immune systems and carries high mortality rates. Researchers studied three common mucormycosis-causing fungi to understand how their outer cell layers interact with the human immune system. They found that all three fungi trigger strong inflammatory responses, which may explain why the disease is so damaging. This research helps us better understand how these infections work and could lead to improved treatments or vaccines.

Clinical Challenges and Predictive Risk Factors for Outcomes in COVID-19–Associated Mucormycosis

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During the COVID-19 pandemic, a dangerous fungal infection called mucormycosis has become a serious complication, especially for patients with uncontrolled diabetes or those taking certain medications. Researchers studied 180 patients with this condition and found that the infection can spread from the sinuses to the eyes and brain, leading to severe outcomes. The most important factors in surviving this infection are early detection, keeping blood sugar controlled, careful use of steroids, and aggressive treatment with antifungal medications and sometimes surgery.

The expression of fungal CotH, human glucose-regulated protein 78 (GRP78), and predicted miRNAs in macrophages and diabetic mice infected with Rhizopus oryzae

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Mucormycosis is a serious fungal infection caused by Rhizopus oryzae that is particularly dangerous for people with diabetes. This study shows that a fungal protein called CotH3 attaches to a human cell receptor called GRP78, allowing the fungus to invade cells more easily in diabetic patients. The research found that diabetes increases GRP78 production, making fungal invasion more likely, while antifungal treatment (liposomal amphotericin B) can reduce the expression of both CotH3 and GRP78.

Research Keyword: mucormycosis