mucormycosis diagnosis

Characterization of the Spatiotemporal Localization of a Pan-Mucorales–Specific Antigen During Germination and Immunohistochemistry

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Researchers developed a test using a special antibody (TG11) that can specifically identify dangerous mold infections (mucormycosis) in tissue samples. The antibody glows when it finds the molds at early stages of growth, even when they first start germinating. Unlike other diagnostic methods, this antibody can tell the difference between dangerous Mucorales molds and other common molds like Aspergillus, which is important for doctors to give the right treatment quickly.

Brazilian task force for the management of mucormycosis

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Mucormycosis is a serious fungal infection that has become more common in Brazil, especially during COVID-19. This medical emergency requires rapid diagnosis through imaging and tissue sampling, combined with aggressive treatment including antifungal medications and surgery to remove infected tissue. The Brazilian government has made these powerful antifungal drugs more available to improve patient survival and reduce the severe complications of this dangerous infection.

The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis

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This study reviews how well a molecular test called PCR can diagnose mucormycosis, a dangerous fungal infection. Researchers analyzed 30 studies covering over 5,000 patient samples and found that PCR works very well for detecting this infection, especially when using samples from the lungs. Blood tests were also effective but slightly less sensitive. The study recommends using PCR as part of updated diagnostic guidelines to help doctors catch this serious infection earlier, potentially improving patient outcomes.

Monoclonal Antibodies Can Aid in the Culture-Based Detection and Differentiation of Mucorales Fungi—The Flesh-Eating Pathogens Apophysomyces and Saksenaea as an Exemplar

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This research developed a special antibody test to quickly identify deadly flesh-eating fungi called Apophysomyces and Saksenaea, which cause serious skin and soft tissue infections. These fungi are difficult to identify because they don’t form spores on standard laboratory media. The new test uses a simple method combining antibody detection with a rapid lateral-flow test, similar to a COVID-19 test, making diagnosis faster and more reliable in hospitals that don’t have access to expensive equipment.

Characterization of the Spatiotemporal Localization of a Pan-Mucorales–Specific Antigen During Germination and Immunohistochemistry

mycolabadmin

Researchers developed a new diagnostic test using a special antibody that can detect Mucorales fungi, which cause a serious infection called mucormycosis. The antibody glows to mark growing fungal threads in tissue samples, helping doctors identify the infection early and distinguish it from other mold infections like Aspergillus. This breakthrough could significantly improve patient outcomes by enabling faster diagnosis and treatment of this aggressive fungal disease.

Evaluation of MucorGenius® Mucorales Real-Time PCR Assay with Formalin-Fixed Paraffin-Embedded Tissue Specimens

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Researchers tested a rapid fungal detection test called MucorGenius® on tissue samples from trauma patients with serious fungal infections. The test successfully identified dangerous mold-like fungi in 92% of infected samples with no false positives. This quick test could help doctors diagnose and treat dangerous fungal wound infections faster in trauma patients.

Disseminated mucormycosis leading to a fatal gastrointestinal perforation in a pediatric case of EBV-associated Hemophagocytic lymphohistiocytosis

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A 12-month-old girl developed a serious immune system disorder called hemophagocytic lymphohistiocytosis triggered by Epstein-Barr virus infection. Despite aggressive treatment, she developed a life-threatening fungal infection caused by mucormycosis that spread throughout her digestive system. The case illustrates how fungal infections can rapidly progress and become fatal in children with severely weakened immune systems, emphasizing the need for doctors to recognize early warning signs like tissue darkening on the skin.

Detection of Mucorales antigen in bronchoalveolar lavage samples using a newly developed lateral-flow device

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Researchers tested a new rapid test device that detects a specific protein released by dangerous mold infections (mucormycosis) in patient respiratory samples. The test uses a special antibody to identify these molds quickly, which is important because mucormycosis can be life-threatening and requires fast treatment. The device showed promise with about 77% accuracy in identifying infections, though larger studies are needed to confirm these findings.

The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis

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Mucormycosis is a dangerous fungal infection that kills many patients. Traditional tests like fungal culture are slow and often miss infections. This comprehensive study of 30 research papers shows that PCR testing is very effective at detecting this fungus, with different specimen types having different success rates. Blood tests were easiest to perform and worked well for screening high-risk patients, while fluid from the lungs was the most accurate.

Detection of Mucorales antigen in bronchoalveolar lavage samples using a newly developed lateral-flow device

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Researchers developed and tested a new rapid test (TG11-LFD) for detecting mucormycosis, a dangerous fungal infection, using a simple device similar to a COVID rapid test. The test detects a specific protein marker released by Mucorales fungi in lung fluid samples. In testing with 62 clinical samples, the new test correctly identified about 77% of actual infections and was negative in about 76% of non-infected samples. This affordable, simple test could help doctors quickly diagnose mucormycosis and start life-saving treatment faster, especially in countries with limited laboratory resources.

Research Keyword: mucormycosis diagnosis