Research Keyword: MTT assay

The efficacy of luliconazole and caspofungin on planktonic and biofilm of Candida albicans from different sources

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Candida albicans, a common yeast infection organism, can form tough protective structures called biofilms that resist antifungal medications. This study tested two antifungal drugs (luliconazole and caspofungin) against Candida in both regular form and biofilm form. The results showed that while these drugs work well against regular Candida cells, they are much less effective against biofilms, which require 15-171 times higher doses to be inhibited. The strongest biofilms came from vaginal infections, suggesting that different infection types may require different treatment approaches.

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Study on Optimization of Liquid Fermentation Medium and Antitumor Activity of the Mycelium on Phyllopora lonicerae

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Scientists optimized how to grow Phylloporia lonicerae fungus in the lab, increasing its production by 142% while cutting growth time by two-thirds. They discovered that certain compounds extracted from this fungus, particularly from a petroleum ether extract, can kill cancer cells and trigger apoptosis. The petroleum ether extract was more effective than the standard cancer drug 5-fluorouracil, especially against esophageal cancer cells, suggesting this fungus could be developed into a natural anti-cancer treatment.

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Chlorophyllum molybdites-synthesized manganese oxide nanoparticles (MnO-NPs): morphology, biocompatibility, and anticancer properties against liver cancer (HepG2) cell line

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Researchers successfully created tiny manganese oxide particles using a wild mushroom called Chlorophyllum molybdites through an environmentally friendly process. These nanoparticles showed strong cancer-fighting ability against liver cancer cells and were effective against a parasite that causes leishmaniasis. The particles were safe for human use with minimal damage to healthy blood cells, making them promising candidates for developing new cancer and parasitic disease treatments.

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Study on Optimization of Liquid Fermentation Medium and Antitumor Activity of the Mycelium on Phyllopora lonicerae

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Researchers improved the production of a medicinal fungus called Phylloporia lonicerae that grows on honeysuckle plants. They developed a better growing medium that produced more fungus in less time. They then discovered that components from this fungus can kill cancer cells, particularly lung and esophageal cancer cells, by triggering a natural cell death process called apoptosis. This work suggests the fungus could be developed into an anti-cancer functional food.

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Evaluation of the Cytotoxicity and Antifungal Efficacy of Crocus sativus (saffron) Petals on Clinical Isolates of Candida albicans

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Researchers tested saffron petals to see if they could fight Candida albicans yeast infections. While saffron extract showed some antifungal activity, it was less powerful than the standard drug fluconazole. However, saffron was very safe and non-toxic to human cells, making it a promising natural alternative therapy worth exploring further.

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Cytotoxic activity of Ganoderma weberianum-sichuanese isolated from the Lower Volta River Basin of Ghana against human prostate carcinoma (PC-3), leukemic T cell (Jurkat), and plasmacytoid dendritic cell (pDC)-derived acute leukemia (PMDC05) cell lines

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Researchers tested a fungus called Ganoderma weberianum-sichuanese from Ghana’s Lower Volta River to see if it could kill cancer cells. They found that extracts from this fungus could effectively suppress the growth of three types of human cancer cells—prostate cancer, T-cell leukemia, and a rare dendritic cell leukemia—without harming normal liver cells. The most promising components were found in certain fractions of the extract, suggesting this natural fungus could potentially be developed into new cancer treatments.

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