Research Keyword: monoclonal antibody

Characterization of the Spatiotemporal Localization of a Pan-Mucorales–Specific Antigen During Germination and Immunohistochemistry

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Researchers developed a test using a special antibody (TG11) that can specifically identify dangerous mold infections (mucormycosis) in tissue samples. The antibody glows when it finds the molds at early stages of growth, even when they first start germinating. Unlike other diagnostic methods, this antibody can tell the difference between dangerous Mucorales molds and other common molds like Aspergillus, which is important for doctors to give the right treatment quickly.

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Monoclonal Antibodies Can Aid in the Culture-Based Detection and Differentiation of Mucorales Fungi—The Flesh-Eating Pathogens Apophysomyces and Saksenaea as an Exemplar

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This research developed a special antibody test to quickly identify deadly flesh-eating fungi called Apophysomyces and Saksenaea, which cause serious skin and soft tissue infections. These fungi are difficult to identify because they don’t form spores on standard laboratory media. The new test uses a simple method combining antibody detection with a rapid lateral-flow test, similar to a COVID-19 test, making diagnosis faster and more reliable in hospitals that don’t have access to expensive equipment.

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Characterization of the Spatiotemporal Localization of a Pan-Mucorales–Specific Antigen During Germination and Immunohistochemistry

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Researchers developed a new diagnostic test using a special antibody that can detect Mucorales fungi, which cause a serious infection called mucormycosis. The antibody glows to mark growing fungal threads in tissue samples, helping doctors identify the infection early and distinguish it from other mold infections like Aspergillus. This breakthrough could significantly improve patient outcomes by enabling faster diagnosis and treatment of this aggressive fungal disease.

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Detection of Mucorales antigen in bronchoalveolar lavage samples using a newly developed lateral-flow device

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Researchers tested a new rapid test device that detects a specific protein released by dangerous mold infections (mucormycosis) in patient respiratory samples. The test uses a special antibody to identify these molds quickly, which is important because mucormycosis can be life-threatening and requires fast treatment. The device showed promise with about 77% accuracy in identifying infections, though larger studies are needed to confirm these findings.

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Evaluating the Potential of Galactosaminogalactan as a Diagnostic Target for Invasive Aspergillosis

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Researchers developed a new test to detect Aspergillus fungal infections using an antibody that recognizes a fungal component called GAG. The test worked very well in mouse studies, reliably detecting the fungus in blood and other body fluids. However, when tested with samples from infected patients, the test could not find GAG in the blood or other fluids, though it could see the fungus in lung tissue. This suggests either patients don’t produce enough GAG in their bloodstream, or something in human biology interferes with detection.

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