Scientists developed a new method to understand how different strains of the fungus Coccidioides posadasii, which causes Valley Fever, respond to temperature changes. By mixing multiple fungal strains together and sequencing their DNA after growing them at different temperatures, they identified a gene that helps determine whether the fungus grows better in hot (body temperature) or cool (environmental) conditions. This discovery could help explain how this dangerous fungus adapts to human infection and may lead to better treatments for Valley Fever.