Researchers in Finland studied how a fast DNA test (PCR) can detect fungal skin infections better than traditional slow culture methods. The new test, called DermaGenius, gives results in just 16 hours instead of 19 days. By 2022, most fungal infection samples were tested using this faster method, which helps doctors treat patients quickly without unnecessary medications.
A 43-year-old man had a persistent facial rash that didn’t improve with standard antifungal treatments. Doctors initially found a fungal infection called Cryptococcus uniguttulatus using culture tests. However, advanced molecular testing (DNA sequencing) revealed he also had a tuberculosis infection in the same skin lesion. Once both infections were treated with appropriate medications, the patient’s rash finally improved. This case shows that sometimes people can have multiple infections at the same location and that newer diagnostic methods are important for finding these hidden infections.
This editorial discusses the growing challenge of fungal infections worldwide, which disproportionately affect people with weakened immune systems. New diagnostic tools using molecular testing can now quickly identify fungal infections, while researchers are developing novel treatments including repurposed drugs and immune-boosting therapies. The article emphasizes that coordinated efforts among doctors, scientists, and public health officials are essential to combat rising antifungal resistance and improve patient outcomes.
Invasive candidiasis is a dangerous fungal infection affecting critically ill hospital patients. Current testing methods like blood cultures are slow and unreliable, so doctors are developing faster tests using DNA detection and biomarkers. A combination of new diagnostic tools and prompt treatment with antifungal medications is essential to improve survival rates and reduce complications from this serious infection.
This study tested different methods to detect a dangerous hospital fungus called Candida auris. Researchers compared growing the fungus on special plates and using molecular tests on patient samples. They found that molecular tests (qPCR) were most sensitive for detecting low levels of the fungus, while growing it on special plates worked well for higher levels. The best approach depends on whether a hospital is dealing with an outbreak or routine screening.