Research Keyword: mitochondrial respiration

Cinchona-based liquid formulation exhibits antifungal activity through Tryptophan starvation and disruption of mitochondrial respiration in Rhizoctonia Solani

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Researchers found that an extract from Cinchona bark, containing the compound quinine, effectively kills rice-damaging fungus Rhizoctonia solani through two mechanisms: starving the fungus of the amino acid tryptophan and disrupting its energy-producing mitochondria. This natural plant-based treatment could serve as an eco-friendly alternative to synthetic fungicides, reducing crop losses from fungal diseases while avoiding the environmental damage and resistance problems associated with chemical pesticides.

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Diet-Derived Advanced Glycation End-Products (AGEs) Induce Muscle Wasting In Vitro, and a Standardized Vaccinium macrocarpon Extract Restrains AGE Formation and AGE-Dependent C2C12 Myotube Atrophy

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This research shows that processed foods high in sugar and fat create harmful compounds called AGEs that can cause muscle loss and weakness. Cranberry extract, which contains natural antioxidants, was found to be particularly effective at blocking AGE formation and preventing muscle cell damage. The study suggests that eating foods containing cranberry extract might help prevent age-related muscle loss and the negative effects of unhealthy Western diets on muscle health.

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Unveiling molecular mechanisms of strobilurin resistance in the cacao pathogen Moniliophthora perniciosa

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Cacao farmers have struggled to control witches’ broom disease, a fungal infection caused by Moniliophthora perniciosa, because the fungus survives even high doses of strobilurin fungicides. This study reveals how the fungus adapts to the fungicide by switching its metabolism to use alternative energy sources, activating detoxification systems, and using an alternative respiratory pathway. Researchers also discovered that prolonged fungicide exposure can create even more resistant mutants with mutations in genes that control fungal growth and gene expression.

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Unveiling molecular mechanisms of strobilurin resistance in the cacao pathogen Moniliophthora perniciosa

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This research reveals how a fungus that causes disease in cacao plants survives treatment with strobilurin fungicides, which are commonly used in agriculture. Scientists discovered that the fungus adapts by reorganizing its metabolism to compensate for the drug’s effects, activating detoxification systems, and in some cases, developing genetic mutations that enhance resistance. Understanding these survival mechanisms could help develop better strategies to control this economically important crop disease.

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