Research Keyword: miRNA

Molecular mechanisms of metal toxicity and transcriptional/post-transcriptional regulation in plant model systems

Plants face serious damage from heavy metals like cadmium, arsenic, and chromium in contaminated soils and water. Scientists are discovering how plants defend themselves through changes in gene expression, special proteins that trap metals, and modifications to their DNA that control stress response genes. Understanding these natural defense mechanisms could help us develop crops that survive in polluted environments and remove heavy metals from contaminated areas, making food safer and protecting human health.

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The expression of fungal CotH, human glucose-regulated protein 78 (GRP78), and predicted miRNAs in macrophages and diabetic mice infected with Rhizopus oryzae

Mucormycosis is a serious fungal infection caused by Rhizopus oryzae that is particularly dangerous for people with diabetes. This study shows that a fungal protein called CotH3 attaches to a human cell receptor called GRP78, allowing the fungus to invade cells more easily in diabetic patients. The research found that diabetes increases GRP78 production, making fungal invasion more likely, while antifungal treatment (liposomal amphotericin B) can reduce the expression of both CotH3 and GRP78.

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