minimum inhibitory concentration – Page 6

Deoxynucleosides as promising antimicrobial agents against foodborne pathogens and their applications in food and contact material surfaces

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Researchers found that two nucleoside compounds (ddA and FdCyd) can effectively kill harmful bacteria like Vibrio and Salmonella that form slimy biofilms on seafood and food preparation surfaces. These compounds work by damaging bacterial cell membranes and preventing bacteria from communicating with each other. When combined with a food additive already used in the meat industry, these nucleosides become even more effective at much lower doses, potentially making food safer while reducing residual chemical effects.

Acute fungal endometritis in women with abnormal uterine bleeding: Clinical and microbiological insights

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This study examined a rare fungal infection of the uterus called fungal endometritis that causes abnormal bleeding and discomfort in women. Researchers found that about 12% of women with unexplained abnormal bleeding had this fungal infection, which was caused by different species of Candida yeast. A simple test using vaginal swabs was not effective for diagnosis; instead, doctors needed to take samples directly from the uterine lining. Treatment with an antifungal medication called voriconazole combined with surgical cleaning was successful in all cases studied.

Molecular Identification, Mycelial Growth Kinetics, and Antimicrobial Potential of Newly Isolated Medicinal Mushroom Fomitopsis pinicola from Bulgaria

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Scientists isolated and studied a medicinal mushroom called Fomitopsis pinicola from Bulgaria. They confirmed its identity using DNA analysis and tested how well it grows on different nutrient media. The mushroom showed strong antimicrobial effects against disease-causing bacteria, especially when extracted with water, making it a promising candidate for developing new antibiotics to fight antibiotic-resistant infections.

Invasive Saprochaete capitata Infection in an Immunocompromised Patient With Acute Myeloid Leukemia: A Case Report

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A 46-year-old man with blood cancer developed a serious fungal infection caused by Saprochaete capitata during chemotherapy. This rare but dangerous fungus was found in his blood and lungs, causing fever and breathing problems. The patient was successfully treated with a combination of two antifungal medications and fully recovered, though this infection typically has a high death rate.

Addressing filamentous fungi-related onychomycosis in the era of antifungal resistance: assessment of Zataria multiflora nanostructured lipid carrier topical gel in a double-blinded clinical trial

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Nail fungal infections (onychomycosis) are difficult to treat, especially as fungi become resistant to standard antifungal medications. Researchers tested a new gel made from Zataria multiflora (Shirazi thyme) packaged in special nanoparticles that help the medicine penetrate the nail better. In a clinical trial comparing this gel to placebo, the Zataria multiflora treatment showed better results after just 2 weeks, with 70% of patients experiencing fungal cure compared to 55% with placebo.

Successful management of Lomentospora prolificans septic arthritis and osteomyelitis in an immunocompetent child: A case report

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A 3-year-old healthy child developed a serious fungal bone and joint infection in the elbow after surgery to repair a broken arm bone. The fungus, called Lomentospora prolificans, is extremely resistant to most medications and can lead to limb amputation. Doctors saved the child’s arm by combining multiple approaches: repeated surgeries to clean out infected tissue, three different antifungal medications taken together, special antibiotic-loaded bone cement placed in the elbow, and antiseptic wound washing. After six months of treatment, the infection was cured and the child could use their arm again.

Molecular epidemiology, diversity, and antifungal susceptibility profiles of clinical and environmental mucorales: a five-year multicenter study in Iran (2018–2023)

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This study examined dangerous mold infections called mucormycosis that became more common during the COVID-19 pandemic, particularly in Iran. Researchers tested over 180 fungal samples from patients and soil to understand which types of molds cause infections and which antifungal medicines work best against them. They found that two medicines, amphotericin B and posaconazole, were most effective, while fungi from soil samples were often more resistant to treatment than those from infected patients. This research helps doctors choose the right treatments for patients with these serious infections.

A Case of Pulmonary Infection Due to Magnusiomyces capitatus in a Non-Immunocompromised Patient with Cerebral Palsy

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A young man with cerebral palsy developed a rare lung infection caused by Magnusiomyces capitatus, a fungus that usually only affects people with weakened immune systems. Doctors diagnosed the infection by analyzing fluid from his lungs and identified the fungus using advanced laboratory techniques. The patient improved after being treated with an antifungal medication called voriconazole. This case highlights that this rare fungal infection can occur in otherwise healthy people, especially those with conditions affecting their ability to clear lung secretions.

Adaptability assessment of Aspergillus niger and Aspergillus terreus isolated from long-term municipal/industrial effluent-irrigated soils to cadmium stress

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Scientists studied two types of fungi that can survive in soil contaminated with cadmium, a toxic heavy metal from industrial waste. These fungi can accumulate and remove cadmium from their environment while producing protective chemicals that help them survive the metal’s toxic effects. The research shows these fungi could potentially be used as a biological solution to clean up contaminated soils, offering a more sustainable alternative to traditional chemical cleanup methods.

Evaluation of the Cytotoxicity and Antifungal Efficacy of Crocus sativus (saffron) Petals on Clinical Isolates of Candida albicans

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Researchers tested saffron petals to see if they could fight Candida albicans yeast infections. While saffron extract showed some antifungal activity, it was less powerful than the standard drug fluconazole. However, saffron was very safe and non-toxic to human cells, making it a promising natural alternative therapy worth exploring further.

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