minimum inhibitory concentration – Page 4

Sandalwood Sesquiterpene (Z)-α-Santalol Exhibits In Vivo Efficacy Against Madurella mycetomatis in Galleria mellonella Larvae

mycolabadmin

Researchers tested sandalwood oil components against a fungal disease called eumycetoma that causes serious skin infections, especially in tropical regions. They found that one component called (Z)-α-santalol was highly effective at killing the fungus and extending survival in laboratory-infected moth larvae, while actually being relatively safe. This natural compound shows promise as a potential new treatment for this neglected disease that currently relies on expensive drugs that are only 40% effective.

Excellent anti-mildew effect of essential oil impregnation on sliced veneer plybamboo and its anti-mildew mechanism

mycolabadmin

Researchers discovered that clove essential oil is highly effective at preventing mold growth on decorative bamboo veneer materials. The natural oil damages fungal cell membranes and disrupts their internal chemistry, killing the mold without toxic chemicals. When bamboo sheets were treated with clove oil before assembly, they showed excellent resistance to common molds. This provides a green, sustainable alternative to harsh chemical treatments while maintaining product quality.

Geographical distribution of Cryptococcus neoformans in Iran, pathogenic factors, and antifungal susceptibility profile

mycolabadmin

Researchers tested pigeon droppings from across Iran to find a dangerous fungus called Cryptococcus neoformans that can cause serious lung infections. They found this fungus in about 8.6% of samples, with more present in some provinces than others. The fungus showed concerning resistance to some common antifungal medications but remained sensitive to others like voriconazole, which could help guide treatment decisions.

Antifungal Agents in the 21st Century: Advances, Challenges, and Future Perspectives

mycolabadmin

This review examines how doctors treat serious fungal infections and the growing problem of fungi becoming resistant to medications. The authors discuss different antifungal drugs, how they work, and why some fungi are becoming harder to treat. They emphasize that controlling fungal resistance requires coordinated efforts across hospitals, farms, and communities, especially since some agricultural pesticides are creating resistant strains that spread to sick patients.

Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

mycolabadmin

Researchers studied yeast infections in urine from hospitalized patients using advanced molecular testing. They found that while Candida albicans was most common, other yeast species were becoming more resistant to antifungal medications. The study used a 21-tube PCR test to identify different yeast species and tested which medications worked best against them. Results showed that newer yeast species were much more likely to resist commonly used antifungal drugs like fluconazole.

Successful management of Lomentospora prolificans septic arthritis and osteomyelitis in an immunocompetent child: A case report

mycolabadmin

A 3-year-old boy developed a serious fungal bone and joint infection caused by Lomentospora prolificans after surgery to fix a broken elbow. This fungus is extremely resistant to most antifungal medications. The infection was successfully treated using multiple approaches: aggressive surgical cleaning, several different antifungal drugs used together, special antibiotic-loaded bone cement, and antiseptic rinses. After two months of intensive treatment, the infection cleared and the child’s arm was saved from amputation.

Conjugation of a Cryptococcus neoformans-derived metalloprotease to antifungal-loaded PLGA nanoparticles treats neural cryptococcosis in an in vitro model

mycolabadmin

Researchers developed special nanoparticles that can cross the protective barrier surrounding the brain by using a protein from a fungal infection. These nanoparticles are loaded with an antifungal drug and can effectively treat cryptococcal brain infections in laboratory tests. This approach offers a new way to deliver medicines to the brain without invasive procedures, potentially helping patients with serious brain infections that are currently difficult to treat.

Acute fungal endometritis in women with abnormal uterine bleeding: Clinical and microbiological insights

mycolabadmin

Women with persistent abnormal uterine bleeding often undergo extensive testing without finding a cause. This study discovered that fungal infections, caused by Candida species, may be responsible for about 12% of such cases. The researchers found that direct sampling of the uterine lining is essential for diagnosis since surface vaginal cultures miss these infections. Treatment with an antifungal medication called voriconazole combined with surgical cleaning of the uterus proved effective in resolving the condition.

Rasamsonia argillacea brain abscess in a lung transplant recipient: an unexpected infection by an unusual fungal pathogen

mycolabadmin

A 65-year-old woman who received a lung transplant developed a rare and serious brain infection caused by an unusual fungus called Rasamsonia argillacea. The infection was difficult to diagnose because it looks similar to more common molds under the microscope. During the investigation of this unexpected infection, doctors discovered that the patient had a rare genetic disorder affecting her immune system that had never been diagnosed. This case highlights how unusual infections can reveal hidden immune system problems.

Antifungal efficacy of caffeic acid and nano-caffeic acid particles against candidiasis: an in vitro study

mycolabadmin

Researchers developed a nano-particle form of caffeic acid, a natural compound found in coffee and tea, to treat oral yeast infections (candidiasis). The nano-version showed better antifungal activity than regular caffeic acid, though not as strong as prescription antifungal drugs. Since it comes from plants with fewer side effects, it could offer an alternative treatment option for patients with candidiasis.

Research Keyword: minimum inhibitory concentration