minimum inhibitory concentration – Page 3

Green Synthesized Copper-Oxide Nanoparticles Exhibit Antifungal Activity Against Botrytis cinerea, the Causal Agent of the Gray Mold Disease

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Scientists have developed tiny copper particles using environmentally friendly methods with beneficial fungi to fight gray mold, a devastating disease in vineyards and crops. These green-synthesized nanoparticles were more effective at stopping the fungus than commercial fungicides currently in use. The research shows this approach could be a sustainable alternative that reduces harmful chemicals used in agriculture while protecting crops more effectively.

Caspofungin therapy in prosthetic valve endocarditis and candidemia due to itraconazole-resistant Candida glabrata (Nakaseomyces glabratus): A case report

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A 13-year-old boy developed a serious fungal infection on his replacement heart valve after recent surgery. The fungal infection was caused by a type of yeast called Candida glabrata that was resistant to the initial antifungal medication. After testing revealed resistance and biofilm formation, doctors switched to caspofungin, a stronger antifungal drug, and the patient recovered successfully.

Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

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Researchers tested five compounds called naphthoquinones for their ability to fight a dangerous fungal infection called cryptococcosis. They found that one compound called 2-MNQ works especially well when combined with the standard antifungal drug amphotericin B, making the treatment more effective. This discovery could lead to better treatments for people with weakened immune systems who are vulnerable to this infection.

Antifungal Effects of the Phloroglucinol Derivative DPPG Against Pathogenic Aspergillus fumigatus

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Scientists developed a new antifungal compound called DPPG based on a natural antibacterial molecule produced by soil bacteria. This synthetic derivative showed strong activity against dangerous fungal pathogens like Aspergillus fumigatus and Candida species, which cause serious infections in humans. The compound works by disrupting the fungal cell membrane, causing it to leak and die. Testing in insect models demonstrated effectiveness comparable to current clinical antifungal medications.

Peritoneal dialysis-related peritonitis caused by Fusarium: a case report and literature review

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A 61-year-old farmer with kidney disease on peritoneal dialysis developed a rare fungal infection caused by Fusarium, a fungus found in soil and water. After initial antibiotics failed, doctors identified the fungus and switched to an antifungal medication called voriconazole. By carefully monitoring drug levels in the patient’s blood and adjusting doses, pharmacists helped achieve a successful recovery with complete resolution of symptoms.

Evaluation of the Cytotoxicity and Antifungal Efficacy of Crocus sativus (saffron) Petals on Clinical Isolates of Candida albicans

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Researchers tested saffron petals as a natural antifungal treatment against Candida albicans, a common fungal infection. While the saffron extract was less potent than the standard drug fluconazole, it showed promise as a safer alternative with minimal toxicity to human cells. The findings suggest saffron petals could be a cost-effective herbal option for treating fungal infections, especially as resistance to conventional antifungals increases.

Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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Researchers studied fungal infections in urine samples from hospitalized patients and found that while the common yeast Candida albicans was most prevalent, other Candida species were increasingly resistant to antifungal medications. Using advanced genetic testing methods, they identified seven different Candida species and tested their resistance to three common antifungal drugs. The findings highlight the growing problem of drug-resistant fungal infections and the need for better diagnostic tools to identify which species is causing infection so appropriate treatment can be selected.

RttA, a Zn2-Cys6 transcription factor in Aspergillus fumigatus, contributes to azole resistance

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Researchers discovered that a protein called RttA helps a common fungus called Aspergillus fumigatus resist azole medicines, which are used to treat serious fungal infections. By studying how this protein works and which genes it controls, scientists found that RttA could be a new target for developing better antifungal treatments. The findings are important because azole-resistant fungal infections are becoming more common worldwide and harder to treat.

A case of flexor tenosynovitis caused by Cyberlindnera rhodanensis – First reported human infection

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A patient developed a fungal wrist infection caused by a yeast never before seen in humans, called Cyberlindnera rhodanensis. The infection required six surgeries and five months of antifungal medications to treat. This case shows that new fungal pathogens can cause serious infections even in healthy people, and highlights the importance of proper identification of organisms in medical cultures.

FTIR Characterization and Bioactivity Assessment of Cinnamomum camphora Essential Oil: Antioxidant, Anti-Enzymatic, and Antifungal Properties Against Phytopathogens

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Camphor tree essential oil has been studied for its ability to fight fungal diseases that harm crops and its potential health benefits. The research found that this natural oil completely stops the growth of several harmful fungi at high concentrations, making it a promising eco-friendly alternative to synthetic pesticides. The oil also showed antioxidant properties and may help regulate blood sugar levels, suggesting uses in both agriculture and medicine.

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