microglial phagocytosis

Microglia and astrocytes mediate synapse engulfment in a MER tyrosine kinase-dependent manner after traumatic brain injury

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After a traumatic brain injury, brain cells called microglia and astrocytes overzealously consume synapses (connections between neurons), which prevents the brain from healing properly. This study shows that these brain cells use a specific protein called MERTK to do this unwanted cleanup. When researchers blocked MERTK in these cells, the mice recovered better motor and cognitive function, had smaller brain injuries, and maintained more healthy synapses.

High-Fat Diet Consumption Induces Neurobehavioral Abnormalities and Neuronal Morphological Alterations Accompanied by Excessive Microglial Activation in the Medial Prefrontal Cortex in Adolescent Mice

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This study shows that eating a high-fat diet during the teenage years can harm brain development and mood in mice. The research found that high-fat diets led to anxiety and depression-like symptoms, along with shrinking brain structures and overactive immune cells in the brain. These findings suggest that teenagers should maintain healthy eating habits, as poor diet during adolescence may have long-lasting effects on mental health.

Research Keyword: microglial phagocytosis

Microglia and astrocytes mediate synapse engulfment in a MER tyrosine kinase-dependent manner after traumatic brain injury

High-Fat Diet Consumption Induces Neurobehavioral Abnormalities and Neuronal Morphological Alterations Accompanied by Excessive Microglial Activation in the Medial Prefrontal Cortex in Adolescent Mice